In drug discovery research, residual solvent measurement is an integral part of purity analysis for synthesis of a drug candidate before it is used for toxicity testing. This is usually carried out using gas chromatography (GC) with direct injection sample introduction. This method requires testing compounds to be soluble at high concentrations (>50 mg/mL, usually in DMSO) to achieve acceptable...

This paper presents the modified design of a bidirectional electrothermal chevron beam microtweezer proposed by J. K. Luo [1]. The original design has been modified to include inward in-plane motion. Thus, the modified design is capable of bidirectional motion. The structures are designed and simulated using COMSOL Multiphysics 4.2a. The bidirectional chevron beam microtweezer shows an in-plane...

conclusions the study showed that the costs associated with cardiovascular diseases were not reasonable for many of these patients and their families. this certainly requires more consideration by managers and policy makers in the health care sector and the implementation of effective interventions. results the study findings showed that the total cost of cardiovascular diseases was 13,074,700 ...

A number of reinforcement learning algorithms have been developed that are guaranteed to converge to the optimal solution when used with lookup tables. It is shown, however, that these algorithms can easily become unstable when implemented directly with a general function-approximation system, such as a sigmoidal multilayer perceptron, a radial-basisfunction system, a memory-based learning syst...