Age is the primary risk factor for osteoarthritis (OA), yet surgical OA mouse models such as destabilization of the medial meniscus (DMM) used for evaluating disease-modifying OA targets are frequently performed on young adult mice only. This study investigates how age affects cartilage and subchondral bone changes in mouse joints following DMM. DMM was performed on male C57BL/6 mice at 4 month...

BACKGROUND The lack of specific and sensitive serum and radiographic biomarkers for early diagnosis of osteoarthritis (OA) as well as for monitoring subtle changes in disease activity in clinical trials has hampered the development of treatments for OA. We previously showed that 1-11E, a human single chain fragment variable (scFv) specific to collagen type II that has been post-translationally ...

This document introduces a framework for mobility management protocols in terms of their key, abstract logical functions. We explain how the framework is capable of presenting a unified view, reducing the clutter that prevents a casual reader from understanding the commonalities between different approaches in mobility management. A first order application of this framework is to enable us to e...

This document defines the requirements for Distributed Mobility Management (DMM) at the network layer. The hierarchical structure in traditional wireless networks has led primarily to centralized deployment models. As some wireless networks are evolving away from the hierarchical structure, a distributed model for mobility management can be useful to them. Requirements Language The key words "M...

A 14-bit 200MS/s current-steering DAC with a novel digital calibration technique called dynamic-mismatch mapping (DMM) is presented. Compared to traditional static-mismatch mapping and dynamic element matching, DMM reduces the nonlinearities caused by both amplitude and timing errors, without noise penalty. This 0.14μm CMOS DAC achieves a state-of-the-art performance of SFDR>78dBc, IM3<-83dBc a...

The paper is devoted to the issues concerning with modeling and simulating of hierarchical database multiprocessor systems. The requirements for a model of parallel database systems are defined. A new computational model of the hierarchical database multiprocessor architecture is described. This model is called DMM (Database Multiprocessor Model) and designed for OLTP workload. It allows us to ...

A brief survey on the most recent results concerning the simulation of PRAMs on DMMs is presented, along with the design of a Shared Memory Simulator (SMS) that is based on a distributed environment provided by many realistic architectures, based on the DMM model. The Shared Memory Simulation Frame (SMS-Frame) will give the opportunity of executing parallel algorithms designed for a variant of ...

Distributed Mobility Management (DMM) is a mobility management solution, where the mobility anchors are distributed instead of being centralized. The use of DMM can be applied in cloud-based (virtualized) Long Term Evolution (LTE) mobile network environments to (1) provide session continuity to users across personal, local, and wide area networks without interruption and (2) support traffic red...

This paper serves as a review and discussion of the recent works on memcomputing. In particular, the universal memcomputing machine (UMM) and the digital memcomputing machine (DMM) are discussed. We review the memcomputing concept in the dynamical systems framework and assess the algorithms offered for computing NP problems in the UMM and DMM paradigms. We argue that the UMM is a physically imp...