Axial distributions of plasma and floating potentials, electron number density and the electron energy distribution function (EEDF) have been measured in the double layer (DL) region of an He discharge constriction. Excitation processes in the constriction region are studied. Using a linearization method for the nonstationary balance equations and choosing appropriate discharge conditions, ...

objective(s): dispersive liquid-liquid microextraction coupled with gas chromatography (gc)-flame ionization detector was developed for the determination of valproic acid (vpa) in human plasma. materials and methods: using a syringe, a mixture of suitable extraction solvent (40 µl chloroform) and disperser (1 ml acetone) was quickly added to 10 ml of diluted plasma sample containing vpa (ph, 1.0...

A simple method for the simultaneous separation and purification of peripheral blood mononuclear cells (PBMC) and polymorphonuclear neutrophil cells (PMNC) was developed for comparative and functional studies in the immune system of the dog. Purity and cell viability were > 95%, yields were similar to those obtained by other techniques but without red blood cell contamination. Differential bloo...

the adsorption study was conducted on three japanese soils with different soil properties to characterize the adsorption pattern of arsenic (as). double tube method was used to find out the effect of soil moisture levels on as adsorption. for this study, besides double tube method, conventional batch method also was used. the as adsorption showed two phase kinetics. an initial and rapid adsorpt...

Clinical trials have a long history of well established, documented, and validated methods for design, conduct, and analysis. Appropriate study design includes sufficient sample size (n) and statistical power, and control of bias to allow for a meaningful interpretation of the results. The number of participants in a clinical trial should always be large enough to provide a sufficiently precise...

We extend Lan and Trost’s (1997,1999) conditional power approach for interim sample size re-estimation to binary data for clinical trials with a noninferiority objective. If conditional power is used to extend a trial, the α level will be inflated. On the contrary if it is used to stop a trial early to claim futility, the α level will be reduced. If inflation does not exceed deflation, then the...

The primary goal in designing a randomized controlled clinical trial (RCT) is to minimize bias in the estimate of treatment effect. Randomized group assignment, double-blinded assessments, and control or comparison groups reduce the risk of bias. The design must also provide sufficient statistical power to detect a clinically meaningful treatment effect and maintain a nominal level of type I er...

Campylobacter concisus has been associated with prolonged mild diarrhoea, but investigations regarding the efficacy of antimicrobial treatment have not been reported previously. We initiated a phase 3, single-centre, randomized, double-blinded, placebo-controlled study comparing the efficacy of 500 mg once-daily dose of azithromycin with a 500 mg once-daily dose of placebo for three days, for t...

OBJECTIVES While bidirectional relationships exist between body weight and physical activity, direction of causality remains uncertain and previous studies have been limited by self-reported activity or weight and small sample size. We investigated the prospective relationships between weight and physical activity. DESIGN Observational analysis of data from the Nateglinide And Valsartan in Im...