Introduction Dynamic contrast enhanced MRI (DCE-MRI) is used to characterize perfusion and extracellular volume in tumors through the tracer kinetic modeling of MRI contrast agents (typically Gd-DTPA). However, the parametric estimates resultant of DCE-MRI may be influenced by several confounding factors, including inter-compartmental water exchange [1]. In contrast to MRI contrast agents, radi...

Aim. To develop a method and obtain proof-of-principle for immunolymphoscintigraphy for identification of metastatic sentinel nodes. Methods. We selected one of four tumour-specific antibodies against human breast cancer and investigated (1), in immune-deficient (nude) mice with xenograft human breast cancer expressing the antigen if specific binding of the intratumorally injected, radioactivel...

Nuclear cardiology practitioners have several new technologies available with which to perform myocardial perfusion single photon emission CT (MPS). These include dedicated small-footprint cardiac scanners, new stationary or semi-stationary three-dimensional detectors, and advanced software algorithms for optimal image reconstruction. These new technologies have been employed to reduce imaging ...

We have generalized the spectral factor analysis and the factor analysis of dynamic sequences (FADS) in SPECT imaging to a five-dimensional general factor analysis model (5D-GFA), where the five dimensions are the three spatial dimensions, photon energy, and time. The generalized model yields a significant advantage in terms of the ratio of the number of equations to that of unknowns in the fac...

The synergistic combination of positron emission tomography (PET) and magnetic resonance imaging (MRI) is likely to become the next generation of dual-modality scanners in medical imaging. These instruments will provide us with accurate diagnoses thanks to the sensitive and quantifiable signal of PET and the high soft-tissue resolution of MRI. Furthermore, patients will receive less radiation d...