Classical and El Tor strains of Vibrio cholerae were examined for production of bacteriophage or bacteriophage-related material by electron microscopy of mitomycin C-induced cultures. The strains were also tested for pathogenicity by using the ligated ileal loops of adult rabbits. Of the 27 strains tested, 25 showed a correlation between the production of bacteriophage-related material and path...

Phage-peptides were prepared from L. lactis ssp. lactis ml3 and L. plantarum yit0068 bacteriophage using a ficin hydrolysis. The ml3 and yit0068 peptides were compared to L. lactis ssp. lactis c2 bacteriophage peptides to determine growth inhibition of C2 host and inhibition of both ml3 and c2 bacteriophage. M17 with .011 mM CaCl2 media with and without phage peptides (2 or 2.5%) were heat trea...

Staphylococcus aureus is a major cause of human and animal infections. Bacteriophage are a class of mobile genetic element (MGE) that carry virulence genes and disseminate them horizontally, including Panton-Valentine leukocidin (PVL), the immune evasion cluster (IEC) associated with human specificity, and enterotoxin A the major toxin associated with food poisoning. S. aureus isolates group in...

For the past three years a study of bacteriophage in its relation to Bact. diphtheriae has been in progress in this laboratory. Incidental to this study observations have been made on the occurrence of the lytic principle active upon this bacterium, with results which somewhat extend our knowledge of the distribution of bacteriophage in general, for it would hardly seem that the conditions gove...

Bacteriophages are viruses that can infect and kill bacteria. Three studies were conducted to determine the efficacy of bacteriophage to prevent an Escherichia coli respiratory infection in broiler chickens. In the first study 3-d-old-birds were challenged with an air sac inoculation of 10(3) cfu of E. coli per mL mixed with either 10(3) or 10(6) pfu of bacteriophage, or 10(4) cfu E. coli mixed...

The infection of Streptococcus pyogenes T25(3) with the temperate bacteriophage T12 results in the conversion of the nontoxigenic strain to type A streptococcal exotoxin (erythrogenic toxin) production. Although previous research has established that integration of the bacteriophage genome into the host chromosome is not essential for exotoxin production, the location of the gene on the bacteri...

Objective(s): Bacteriophages are infectious replicating entities that are under consideration as antimicrobial bioagents to control bacterial infections. As an alternative or supplement to antibiotics, bacteriophages can be used to circumvent the resistance to existing antibiotics. The aim of this study was to assess the synergistic effect of a naturally isolated phage...

The protein product of gene 11 of bacteriophage T4D was purified to apparent homogeneity from a bacteriophage culture in which this particular structural protein had not yet become incorporated into the mature bacteriophage particle. Monomer and apparent trimer molecular weights were determined to be approximately 24,000 and 70,000, respectively, and an amino acid analysis was performed. The ki...