Objective(s): Production of a recombinant and immunogenic antigen using dengue virus type-3 envelope protein is a key point in dengue vaccine development and diagnostic researches. The goals of this study were providing a recombinant protein from dengue virus type-3 envelope protein and evaluation of its immunogenicity in mice. Materials and Methods: Multiple amino acid sequences of different i...

one of the most important measures, in order to increase animal products and reduce imports, is the industrialization of animal husbandry units, specially the dairy cattle. the condition of milk production would be improved by this industrialization, which is in the direction of increasing the efficiency of milk production units. the purpose of this study is calculate , the efficiency of the tr...

Abstract The Vernier effect and harmonic have attracted ever-increasing interest due to their freely tailored spectrum envelope in tunable laser, modulator, precision sensing. Most explorations mainly focused on configuring two isolated optical resonators, namely the reference resonator. However, this configuration requires a stable resonator guarantee robust readout, posing significant challen...

Background: Many elderly individuals complain of difficulty in understanding speech in noise despite having normal hearing thresholds. According to previous studies, auditory training leads to improvement in speech-in-noise perception, but these studies did not consider the etiology, so their results cannot be generalized. The present study aimed at investigating the effectiveness of envelope-b...

We report experimental and analytical results of a fiber-optic link that supports simultaneous transmission of baseband data and subcarrier multiplexed control-data channels. A novel transmitter design is used to optoelectronically combine baseband and subcarrier channels onto the optical carrier using a differential Mach–Zehnder (MZ) interferometer modulator. Microwave direct detection of the ...

Human immunodeficiency virus-1 (HIV-1) Tat, a nuclear transactivator of viral gene expression, has the unusual property of being released by infected cells. Recent studies suggest that extracellular Tat is partially sequestered by heparan sulfate proteoglycans. As a consequence, Tat is concentrated on the cell surface and protected from proteolytic degradation, thus remaining in a biologically ...

In this paper, the preferred region of design parameters for quasi-normalized equations of single-axis attitude control of rigid spacecraft using pulse-width pulse-frequency modulator (PWPFM) is presented for rest-to-rest maneuvers. Using the quasi-normalized equations for attitude control reduces the system parameters, that is, the moment of inertia, the filter gain, and the maximum torque of ...

Regulation of the proteasome system, which is responsible for the generation of most MHC class I-bound peptides, occurs through the interaction of the 20S proteasome with several regulatory proteins. One of these is PI31, which acts in vitro as an inhibitor of proteasome activity. Here, we demonstrate that, rather than inhibiting proteasome function, PI31 acts as a selective modulator of the pr...

TorsinA is an essential AAA+ ATPase requiring LAP1 or LULL1 as cofactors. The dynamics of the Torsin/cofactor system remain poorly understood, with previous models invoking Torsin/cofactor assemblies with fixed stoichiometries. Here we demonstrate that TorsinA assembles into homotypic oligomers in the presence of ATP. Torsin variants mutated at the "back" interface disrupt homo-oligomerization ...

The combined analog locked-loop universal modulator (CALLUM) is a radio-frequency (RF) transmitter topology which produces a linear output through the use of nonlinear, but highly efficient, RF power amplifiers. This is achieved through careful phasing of two constant-envelope vectors, each derived from voltage-controlled oscillators. The system up-converts and amplifies a baseband signal withi...