Soluble epoxide hydrolase enzyme is a promising therapeutic target for hypertension, vascular inflammation, pain and some other risk factors of cardiovascular diseases. The most potent sEH inhibitors reported in the literature are urea-based ones which often have poor bioavailability. In this study, in a quest for finding potent inhibitors of soluble epoxide hydrolase, some 4,6-disubstituted py...

Microsomal epoxide hydrolase, a major antigenic marker of putative preneoplastic hepatocytes was studied in hyperplastic liver nodules and in normal liver tissue. Hyperplastic nodules induced by two different protocols contained 2to 3-fold higher specific activities of microsomal epoxide hydrolase than did normal surrounding tissue. However, no increase in cytosolic epoxide hydrolase determined...

Carbamazepine is metabolized to an active metabolite known as carbamazepine-10,11-epoxide, or simply the "epoxide" metabolite. The presence of this metabolite can have clinically significant implications in therapeutic drug monitoring of carbamazepine, but accurate quantification of the epoxide metabolite is currently limited to chromatographic techniques. In this study, mathematical equations ...

Microsomal epoxide hydrolase, a major antigenic marker of putative preneoplastic hepatocytes was studied in hyperplastic liver nodules and in normal liver tissue. Hyperplastic nodules induced by two different protocols contained 2to 3-fold higher specific activities of microsomal epoxide hydrolase than did normal surrounding tissue. However, no increase in cytosolic epoxide hydrolase determined...

Oxidation products from the autoxidation of three triacylglycerol standards have been analyzed using reversed-phase high-performance liquid chromatography (RP-HPLC) coupled to mass spectrometry via an atmospheric pressure chemical ionization (APCI) source. Triolein, trilinolein and trilinolenin were autoxidized in the dark at 50–608C until the oxidation products represented approximately 30% of...

Single-walled and multi-walled carbon nanotubes (CNTs) were functionalized with carboxyl groups and dispersed in a polymer containing an epoxide group. We have then observed experimentally that mutual chemical reaction between the functional groups on the CNTs with the polymer epoxide group can enhance, two-fold, both the tensile strength and elastic modulus, E, of single walled CNT/polymer com...

We have utilized a DNA clone complementary to epoxide hydrolase niRNA as a probe to examine the level of the inRNA in persistent hepatocyte nodules and hepatomas induced by the Solt-Farber chemical carcinogenesis procedure. Epoxide hydrolase inRNA is increased 14-fold in nodules as compared to the level in normal liver. When rats with liver nodules were administered phénobarbital, an inducer o...

Epoxide hydrolases play an important role in the biodegradation of organic compounds and are potentially useful in enantioselective biocatalysis. An analysis of various genomic databases revealed that about 20% of sequenced organisms contain one or more putative epoxide hydrolase genes. They were found in all domains of life, and many fungi and actinobacteria contain several putative epoxide hy...

Compounds isolated from essential oils play an important role in the prevention and treatment of cancer. Monoterpenes are natural products, and the principal constituents of many essential oils. The aim of this study was to investigate the cytotoxic potential of p-menthane derivatives. Additionally, analogues of perillyl alcohol, a monoterpene with known anticancer activity, were evaluated to i...

Electrochemical impedance measurements were used for the detection of single-strand DNA sequences using a peptide nucleic acid (PNA) probe layer immobilized onto Si/SiO2 chips. An epoxysilane layer is first immobilized onto the Si/SiO2 surface. The immobilization procedure consists of an epoxide/amine coupling reaction between the amino group of the PNA linker and the epoxide group of the silan...