the thermo-oxidative degradation of two viscous liquid resins of 1,2- poly-butadiene  (1,2-pbd) and 1,4- polybutadiene  (1,4-pbd) have been studied by differential scanning calorimetry (dsc) and thermogravimetry analy-sis  (tga). to  study  further,  the  effect of flm  thickness on oxidation kinetics was periodically studied by tracing the weight of the samples to make comparison with dsc resu...

The reactions with DNA and mutagenic activities toward Salmonella typhimurium TA 100 of the R,S,S,R and S,R,R,S enantiomers of anti-1,2,-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydro-5-methylchrysene (anti-5-MeC-1,2-diol-3,4-epoxide), anti-5-MeC-7,8-diol-9,10-epoxide, and anti-6-MeC-1,2-diol-3,4-epoxide were compared because among these compounds only the R,S,S,R enantiomer of anti-5-MeC-1,2-diol-3,4-...

Background: Enantiopure epoxides are important intermediates in the synthesis of high-value chiral chemicals. Epoxide hydrolases have been exploited in biocatalysis for kinetic resolution of racemic epoxides to produce enantiopure epoxides and vicinal diols. It is necessary to obtain sufficient stable epoxide hydrolases with high enantioselectivity to meet the requirements of i...

The reactions with DNA and mutagenic activities toward Salmonella typhimurium TA 100 of the R,S,S,R and S,R,R,S enantiomers of antil,2,-dihydroxy-3,4-epoxy-l,2,3,4-tetrahydro-5-methylchrysene (anti5-MeC-l,2-diol-3,4-epoxide), an»i-5-MeC-7,8-diol-9,10-epoxide, and «nf/-6-MeC-l,2-diol-3,4-epoxide were compared because among these compounds only the H,S,S,K enantiomer of anri-5-MeC-l,2-diol-3,4e...

We have examined the selectivity of rat liver microsomal epoxide hydrolase (EC 3.3.2.3) toward all of the possible positional isomers of benzo-ring diol epoxides and tetrahydroepoxides of benz[a]anthracene, as well as the 1,2-diol 3,4-epoxides of triphenylene. This set includes compounds with no bay region in the vicinity of the benzo-ring, a bay-region diol group, a bay-region epoxide group, a...

background: resistance to most antimalarial drugs has encouraged the development of novel drugs. an alternative source for discovering such drugs is natural products. some ferulago species are used in folk medicine for their sedative, tonic and anti-parasitic effects. besides, coumarins isolated from this genus found to have in vitro anti-leishmanicidal effect. the present study is aimed to eva...

The mechanical properties of graphene oxide (GO) are of great importance for applications in materials engineering. Previous mechanochemical studies of GO typically focused on the influence of the degree of oxidation on the mechanical behavior. In this study, using density functional-based tight binding simulations, validated using density functional theory simulations, we reveal that the defor...

Soluble epoxide hydrolase (sEH) is suggested to alter the mode of action and increase the toxic potency of fatty acid epoxides. To characterize the structural features necessary for sEH-dependent epoxy fatty acid toxicity, 75 aliphatic compounds were assayed for cytotoxicity in the presence and absence of sEH. Three groups of aliphatic epoxide-diol pairs were described by their observed differe...

The stereochemistry of diol epoxide formation in mouse epidermis upon topical applicationof [3H]-l/f,2A-dihydroxy-l,2-dihydro-5-methylchrysene (|3H|-5-MeC-l/f,2A-diol)and |3Hl-6-MeC-lÄ,2Ä-diol, and the tumorigenicityin mouse skin and in newborn mice of the R,S,S,R and S,R,K,S enantiomers of l,2-dihydroxy-3,4-epoxy-l,2,3,4-tetrahydro-5methylchrysene (5-MeC-l,2-diol-3,4-epoxide), 5-MeC-7,8-diol...

The template effect of 14-3-3 protein on the chemical ligation of fusicoccin derivatives containing an epoxide group and the pentapeptide QSYDC was investigated. HPLC analysis of the epoxide-opening reaction demonstrated that 14-3-3ζ protein improves the yield of the conjugate product compared to the protein-free control.