Erythema multiforme may be placed on a disease continuum that includes Stevens-Johnson syndrome and toxic epidermal necrolysis. It was first described in 1866 by Hebra as a skin disease with symmetrically distributed red papules, evolving within several days to form annular or iris-like shapes or blisters. The term multiforme described this evolution of primary lesions into different forms. In ...

Erythema multiforme (EM) is an acute mucocutaneous hypersensitivity reaction characterised by a skin eruption, with or without oral or other mucous membrane lesions. Occasionally EM may involve the mouth alone. EM has been classified into a number of different variants based on the degree of mucosal involvement and the nature and distribution of the skin lesions. EM minor typically affects no m...

Adverse skin reactions to drugs are frequent, with rates of reaction to many commonly used drugs exceeding 1%. We describe a 29-year-old woman admitted with a history of itching, rash, vesicles on her hands and soles, and edema on her tongue and oropharynx after trimethoprim-sulfamethoxazole, ciprofloxacin, methenamine anhydromethylene citrate, piroxicam, azithromycin, and ceftriaxone intake. E...

Although the existence of photodistributed erythema multiforme has been recognized for years, few cases have been described to date. It is an uncommon, and probably underdiagnosed, skin disorder that can affect individuals of both sexes and all ages. It has been associated with drugs, reactivation of herpes simplex virus infection, and polymorphous light eruption. A diagnosis is made on the bas...

4-year-old child presented oral and genital eruptions for 2 days, he had history of herpetic stomatitis 3 days before. Examination revealed oral painful erosive lesions with genital erythematous purpuric patch mimiking atypical target-like lesions . No others cutaneous lesions were observed. Skin biopsy showed apoptotic individual keratinocytes, degeneration of basal keratinocytes and intercell...

The clinical course of leprosy is often interrupted by reactions, which are acute inflammatory episodes that can be classified as type I or type II. Type II reactions can present as cutaneous lesions that resemble erythema multiforme (EM). EM is classically associated with drug allergies or pre-existing viral infections. However, the differential diagnostic criteria of the diverse causative age...

Figure 2: Dermoscopy of typical target lesion in erythema multiforme: White arrow corresponding to the central dusky zone shows clods of different colors – red, blue, purple, and black. The yellow arrow shows a plain featureless area corresponding to the pale edematous zone, and the black arrow shows homogenous erythema corresponding to the outer red ring. A few short linear vessels were also s...

334 Ann Dermatol Received May 30, 2014, Revised June 30, 2014, Accepted for publication July 4, 2014 Corresponding author: Alper Evrensel, Department of Psychology, Uskudar University, Etiler Clinic, İstanbul 34330, Turkey. Tel: 90-212-270-12-92, Fax: 90-212-270-17-19, E-mail: alperevrensel @gmail.com This is an Open Access article distributed under the terms of the Creative Commons Attribution...