It was with great interest that we read the correspondence of Mahler and Fritzler on our recent European Vasculitis Study Group (EUVAS) study describing the performance of immunoassays for antineutrophil cytoplasmic antibodies (ANCA) in patients with ANCA-associated vasculitides (AAV). In their letter, Mahler and Fritzler raise some interesting points, mainly related to (i) test result interpre...

BACKGROUND Serum desmoglein enzyme-linked immunosorbent assay (ELISA) is used for the diagnosis and monitoring of pemphigus diseases. OBJECTIVES To compare the diagnostic accuracy of salivary antidesmoglein (Dsg) 1 and 3 ELISA in the diagnosis of pemphigus vulgaris (PV) patients with that of serum desmogleins ELISA. METHODS Eighty-six untreated PV patients and 180 age- and sex-matched PV-fr...

Epidemiological studies of neuromyelitis optica (NMO) in Jamaica are lacking. Here we reviewed the clinical records of 700 patients undergoing neurological evaluation at the Kingston Public Hospital, the largest tertiary institution in Jamaica over a 4 month period. We investigated the diagnostic utility of Aquaporin-4 ImmuneglobulinG (AQP4-IgG) testing in 36 consecutive patients with a diagnos...

The first commercial indirect immunofluorescence assay (IFA) using Euroimmun Biochip technology was evaluated for the serodiagnosis of immunoglobulin G (IgG) and IgM antibodies against yellow fever virus (YFV) and was compared with the plaque reduction neutralization test (PRNT), which is currently the gold standard test for YFV. An overall correlation between the tests of 98.7% was established...

Major risk factors for the spread of measles in displaced populations are: poor vaccination coverage, mass migration causing international diseases and high density refugee population camps. The aim this study was to determine serologic evidence IgM antibodies among children two IDP camps (Ungwan zawu Hayin Nariya) situated Kaduna South North. Sample consisted 192 consenting About four (4) mill...

It was with great interest that we read the correspondence of Mahler and Fritzler on our recent European Vasculitis Study Group (EUVAS) study describing the performance of immunoassays for antineutrophil cytoplasmic antibodies (ANCA) in patients with ANCA-associated vasculitides (AAV). In their letter, Mahler and Fritzler raise some interesting points, mainly related to (i) test result interpre...

Abstract Background T-cell responses are a crucial constituent in the adaptive immunity to SARS-CoV-2 and can be quantified using interferon-gamma (IFN-γ) release assays (IGRAs). This study aimed at comparing results of two commercial IGRA systems, EUROIMMUN Quan-T-Cell Oxford Immunotec T-SPOT.COVID, presenting first head-to-head comparison these for evaluation SARS-CoV-2-specific activity. Met...

Background: Anti-cytosolic 5′-nucleotidase 1A (anti-cN1A) antibodies were proposed as a biomarker for the diagnosis of inclusion body myositis (IBM), but conflicting specificity and sensitivity evidence limits its use. Our study aimed to assess diagnostic accuracy anti-cN1A in cohort patients who underwent line immunoassay suspected idiopathic inflammatory myopathies (IIM). We also assessed agr...

The publisher regrets we have been made aware of the below errors:1)In Table 15, row NOVEOS chemiluminescent assay is written “utilizes 40 ?L (0.04 ml) sample per result”. correct value would be “4 (0.004 ml)" result.2)In 16, “NOVEOS menu has 79 available allergens, consisting 69 extracts and 10 molecular allergens”. It should say continues to increase it 152 total allergens with 108 44 compone...