A protein of 33 kDa (p33) that tightly binds to the globular domains of the first complement component, C1q, is thought to serve as the major C1q receptor (gC1qR) on B cells, neutrophils, and mast cells. However, the cellular routing and the subcellular localization of p33/gC1qR are unknown. We have performed confocal laser-scanning microscopy and found that p33/gC1qR is present in intracellula...

BACKGROUND The purpose of this study was to investigate the aging changes of macromolecular synthesis in animal cells. METHODS We studied 10 groups of mice during development aged from fetal day 19 to postnatal month 24. They were injected with 3H-leucine, a precursor for protein synthesis, sacrificed and the pancreatic tissues were taken out, fixed and processed for light and electron micros...

Despite advances in diagnosis and treatment, heart failure (HF) still remains one of the unsolved problems modern cardiology. The appearance progression HF is preceded by development maladaptive myocardial remodeling. In this regard, search for new molecules therapeutic action aimed at preventing remodeling undoubted interest. context, galaninergic system seems to be a promising target. To date...

pls see pdf.

Alcohol dependence is correlated with a wide spectrum of medical, psychological, behavioral, and social problems. Acute alcohol abuse causes damage to and functional impairment of several organs affecting protein, carbohydrate, and fat metabolism. Mitochondria participate with the conversion of acetaldehyde into acetate and the generation of increased amounts of NADH. Prenatal exposure to ethan...

The aging changes of intramitochondrial protein synthesis in hepatocytes of several groups of litter mate mice at various ages, from fetal day 19, to postnatal newborn, adult month 1, 6, year 1 and 2, by means of electron microscopic radioautography after the injections with H-leucine were studied. From the results, it was found that some of the mitochondria in the hepatocytes were labeled with...

alzheimer’s disease (ad) is a progressive neurodegenerative disorder that affects regions of the brain that control cognition, memory, language, speech and awareness to one’s physical surroundings. the pathological initiation and progression of ad is highly complex and its prevalence is on the rise. in his study, alzheimer's disease was induced with single injection of amyloid-β (aβ) pepti...