Knots in proteins have been proposed to resist proteasomal degradation. Ample evidence associates proteasomal degradation with neurodegeneration. One interesting possibility is that indeed knotted conformers stall this machinery leading to toxicity. However, although the proteasome is known to unfold mechanically its substrates, at present there are no experimental methods to emulate this parti...

This study proposes a method to predict the evolution of compression force during degradation lithium-ion battery under packed conditions. The total comprises irreversible and reversible forces. former is estimated using multivariate machine learning method, whereas latter by combining phenomenological modeling. For predicting force, impedance-related features are extracted their correlations w...

Infections produce significant respiratory muscle weakness, but the mechanisms by which inflammation reduces muscle force remain incompletely understood. Recent work suggests that caspase 3 releases actin and myosin from the contractile protein lattice, so we postulated that infections may reduce skeletal muscle force by activating caspase 3. The present experiments were designed to test this h...

Unencapsulated, exfoliated black phosphorus (BP) flakes are found to chemically degrade upon exposure to ambient conditions. Atomic force microscopy, electrostatic force microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, and Fourier transform infrared spectroscopy are employed to characterize the structure and chemistry of the degradation process, suggesting that O2...

Corrosion significantly affects the structural behavior of members in a connection (i.e., thickness steel plates, preload force bolts, and friction factor plates). Safety assessment corroded frames beam-to-column connection, beams, or columns) has been major concern engineering. In this work, an experiment accelerated corrosion testing is carried out to obtain specimens connected with high-stre...

BACKGROUND A sudden mechanical insult to the spinal cord is usually caused by changing pressure on the surface of the spinal cord. Most of these insults are mechanical force injuries, and their mechanism of injury to the spinal cord is largely unknown. METHODS Using a compression-driven instrument to simulate mechanical force, we applied mechanical pressure of 0.5 MPa to rat dorsal root gangl...

Individual component reliability can often be estimated from degradation signals. In this paper, we examine the utility of the wavelet transform in pre-processing degradation signals for on-line reliability estimation. Wavelet preprocessing facilitates examination of degradation signals in both the timeand frequency-domains, simultaneously. Neural networks are used for forecasting the degradati...

The successive growth of the population, degradation natural environment, and development civilization diseases force a continuous increase in production high-quality food [...]