We have studied the receptors for phorbol ester tumor promoters in a set of cultures of mammary cell lines derived from the same dimethylbenz(a)anthracene-induced tumor. These lines differ in cell morphology and in the ability to form domes either spontaneously or under the action of inducers. Tumor promoters inhibit dome formation. We asked whether receptors for tumor promoters could also medi...

In the architecture of the mosque, the light entering into the dome is a functional necessity and due to the structure, the weight of the dome and its one or more shells has caused limitations in any kind of skylights to be encumbered. The research main question is that due to the mechanism of the dome parts, how the creation and the entering of skylights to the dome were done. The research met...

Salt domes, an important geological structure, are closely related to the formation of petroleum reservoirs. In many cases, no explicit strong reflector exists between a salt dome and neighboring geological structures. Therefore, interpreters commonly delineate the boundaries of salt domes by observing a change in texture content. To stimulate the visual interpretation process, we propose a nov...

The Sonic hedgehog (Shh) signaling pathway regulates developmental, homeostatic, and repair processes throughout the body. In the skin, touch domes develop in tandem with primary hair follicles and contain sensory Merkel cells. The developmental signaling requirements for touch dome specification are largely unknown. We found dermal Wnt signaling and subsequent epidermal Eda/Edar signaling prom...

Basal cell carcinoma (BCC) is characterized by frequent loss of PTCH1, leading to constitutive activation of the Hedgehog pathway. Although the requirement for Hedgehog in BCC is well established, the identity of disease-initiating cells and the compartments in which they reside remain controversial. By using several inducible Cre drivers to delete Ptch1 in different cell compartments in mice, ...

Background: The technique of vertical dome division or tip defining, involves incising the lateral crura and vestibular skin at or lateral to the dome or tip defining point. The incision di-vides the lower lateral cartilage into a lateral segment and a medial segment, which are advanced anteriorly and sutured together to increase tip projection. The present study aimed at assessing a new vertic...