Pregabalin is a gamma-aminobutyric acid (GABA) analog used for the treatment of partial epilepsy, neuropathic pain, fibromyalgia, and generalized anxiety disorder. As a GABA analog, there has been some concern about its abuse liability. The number of case reports on the abuse potential of pregabalin has increased (1,2,3,4). To our knowledge, this is the third case report of pregabalin use disor...

Here is presented the whole-genome sequence of Streptococcus thermophilus APC151, isolated from a marine fish. This bacterium produces gamma-aminobutyric acid (GABA) in high yields and is biotechnologically suitable to produce naturally GABA-enriched biofunctional yogurt. Its complete genome comprises 2,097 genes and 1,839,134 nucleotides, with an average G+C content of 39.1%.

Changes in extra and intracellular neurotransmitter amino acids concentration in the early stage of acute cerebral ischemia have been reported. In this the study, serum level of gamma aminobutyric acid (GABA) and L-Arginine in acute ischemic stroke patients was assessed. 60 patients with acute ischemic stroke and sixthy healthy volunteers as a control group were assessed. Serum GABA was measure...

The draft genome sequences of Bifidobacterium angulatum GT102 and Bifidobacterium adolescentis 150 strains isolated from the human intestinal microbiota are reported. Both strains are able to produce gamma-aminobutyric acid (GABA). Detailed genomes analysis will help to understand the role of GABA in the functioning of gut-brain axis.

The precedence effect is a prerequisite for faithful sound localization in a complex auditory environment, and is a physiological phenomenon in which the auditory system selectively suppresses the directional information from echoes. Here we investigated how neurons in the inferior colliculus respond to the paired sounds that produce precedence-effect illusions, and whether their firing behavio...

Background: It has been suggested that organophosphates may inhibit gamma-aminobutyric acid (GABA) metabolism in synaptosomal preparations. In the present investigation, we have assessed the interaction between paraoxon and the GABA system at synaptic level. Methods: Synaptosomes were prepared from male Wistar rats (200-250 g). Cerebral cortex was dissected and homogenized, then centrifuged at ...

Abstract. Syukur S, Safrizayanti, Zulaiha Supriwardi E, Fahmi A, Nurfadilah KK, Purwati E. 2021. Potential antioxidant activity of Lactobacillus fermentum KF7 from virgin coconut oil products in Padang, West Sumatra, Indonesia. Biodiversitas 23: 1628-1634. The isolation and characterization five commercial Virgin Coconut Oil (VCO) circulating the local market Padang city were conducted. In this...

Gamma-aminobutyric acid (GABA) metabolism was studied in rats chronically exposed to 2.86 GHz microwaves at an incident power level of 10 mW/cm or acutely exposed to incident power levels of 40 or 80 mW/cm. No changes occurred in whole brain GABA levels or L-glutamic decarboxylase activity following these exposures. These results suggest that an altered GABA metabolism is not involved in report...

microscopy; kainic acid, (KA); lithium-pilocarpine, (LiPC); HS, hippocampal sclerosis; GABA, Gamma-aminobutyric acid; CNS, central nervous system; GER, granuler endoplasmic reticulum= rER, rough endoplasmic reticulum; DNA, deoksiribonucleic acid; RNA, ribonucleic acid; SE, status epilepticus; CA1, cornu ammons 1; CA2, cornu ammons 2; CA3, cornu ammons 3; GD, gyrus dentatus; DGC, dentate granule...

The effects of implantation of gamma-aminobutyric acid (GABA) and serotonin (5-HT) into the arcuate nucleus (ARC) on serum luteinizing hormone (LH) and prolactin (PRL) were examined in the conscious ovariectomized rat. Following implantation of 5-HT, but not GABA, serum PRL was significantly increased. While 5-HT did not affect pulsatile LH secretion, GABA significantly decreased the mean LH co...