BACKGROUND The risk of developing a second primary tumour in patients with gastric carcinoma is higher than among the general population. The aim was to investigate the clinicopathological characteristics of the second primary cancers in patients with gastric cancer in this study. PATIENTS AND METHODS In the retrospective study, patients with gastric cancers were evaluated between 1995 and 20...

It has been previously reported (M. Yashiro et al., Jpn. J. Cancer Res., 84: 883-886, 1994) that a growth factor secreted by human gastric fibroblasts stimulated proliferation of human scirrhous gastric carcinoma cells in vitro, suggesting a similar paracrine action in the gastric submucosa. The present study established the identity of the growth factor as keratinocyte growth factor (KGF). Inc...

OBJECTIVES This study investigated the PKCα protein expression in gastric carcinoma, and correlated it with clinicopathological parameters. The prognostic significance of PKCα protein expression in gastric carcinoma was analyzed. METHODS Quantitative real-time PCR test was applied to compare the PKCα mRNA expression in tumorous and nontumorous tissues of gastric carcinoma in ten randomly sele...

Most gastric neuroendocrine tumours are well differentiated and considered as neuroendocrine neoplasms, whilst poorly differentiated lesions are considered as neuroendocrine carcinomas and account for only 6-16% of gastric neuroendocrine tumours. Gastric mixed adenoneuroendocrine carcinomas are rare malignancies usually composed of a neuroendocrine carcinoma and an adenocarcinoma with a variabl...

All gastric carcinomas are originated from foveolar (stem/basal) cells, in practice. The most important development in this field is the detection of H.pylori’s role in the development of chronic gastritis as an important etiological factor. In most examples, they develop on the ground of intestinal metaplasia and chronic atrophic gastritis, and led by various stages of dysplasia, carcinoma in ...

The activation of Hedgehog (Hh) signaling has been implicated in the growth of various tumor types, including gastric carcinoma. However, the precise mechanisms of Hh activation and suppression of tumor growth by the blockade of Hh signaling in gastric carcinoma cells remain unknown. The aim of this study was to elucidate the mechanism of abnormal Hh signaling and the key molecules contributing...

Gastric metastasis from breast carcinoma occurs rarely and generally derives from infiltrating lobular carcinoma (ILC) rather than infiltrating ductal carcinoma (IDC). Here, we reported a case of breast infiltrating ductal carcinoma metastasis to stomach in a 58-year-old woman, who experienced epigastric pain and abdominal distention for ten days. Gastric endoscopy was performed and revealed er...

The aim of the study was to ascertain presence of Helicobacter pylori in gastric carcinoma as a responsible promoter of inflammatory-regenerative changes, which lead to pathological differentiation and transformation of normal epithelial cells into intestinal type and, in progression, cause epithelial dysplasia that develops into early gastric carcinoma. The paper presents prospective study tha...

Shimizu1) in our clinic has studied, by Sawasaki's paper-chromato graphic method,2) the state of occurrence of free amino acids in the gastric juice mainly before operation of surgical patients with gastric or duodenal ulcer and gastric carcinoma. In the work to be reported here, the free amino acids of the gastric juice were collected, by means of ion-exchange resin recommended by Partridge3)4...

BACKGROUND Laparoscopic and endoscopic cooperative surgery (LECS) was performed for the local resection of gastrointestinal stromal tumors (GIST). LECS enables less resection of the lesion area and preserves function. Furthermore, LECS can be safely performed and independent of tumor location. However, LECS is not usually used for cases involving gastric carcinoma because it may seed tumor cell...