Background: Chronic inflammation and dys-regulation of the immune system mechanisms are now well established as primary triggers of gastric cancer and peptic ulcer disease. Galectin-9 (Gal-9) is a member of the galectin family and known as an inducer of cell aggregation, adhesion and apoptosis. Gal-9 interaction with its main ligand T-cell immunoglobulin and mucin domain protein-3 (Tim-3) leads...

Aqueous (hydrophilic) and chloroform (Lipophilic) extracts of nine medicinal plants currently used in traditional medicine, in Egypt, to treat some gastrointestinal tract (GIT) disorders were tested for their gastro-protective effect against the incidence of peptic ulcer. Indomethacin-induced ulcer in a rat model was used for this testing. Mentha microphylla, Brassica oleracea Capitata (Cabbage...

Aqueous (hydrophilic) and chloroform (Lipophilic) extracts of nine medicinal plants currently used in traditional medicine, in Egypt, to treat some gastrointestinal tract (GIT) disorders were tested for their gastro-protective effect against the incidence of peptic ulcer. Indomethacin-induced ulcer in a rat model was used for this testing. Mentha microphylla, Brassica oleracea Capitata (Cabbage...

Gastric endoscopy was performed in the 24 Persian Arab horses from several race training in Tehran and Tabriz for detection of gastric ulcer. Gastric ulcer was evident in 14 Persian Arab horses (58.3%). Ten out of 14 ulcers were in nonglandular region of the stomach. The horses with the history of long term treatment with non-steroidal anti-inflammatory drugs (NSAIDs) had high prevalence of the...

Objective: In order to study the gastroprotective effect of Aegle marmelos extract (AM), this study was undertaken on aspirin-induced ulcerogenesis in cannulated free-moving rats. Background: Most of the non-steroidal anti-inflammatory drugs (NSAIDs) including aspirin (ASP) cause gastric ulcer. The efficacy of several plants for the treatment of gastroduodenal disease is confirmed by clinical r...

This review summarizes the involvement of centrally and peripherally applied melatonin, a major hormone of pineal gland, in the mechanism of gastric mucosal integrity, gastroprotection and ulcer healing. Melatonin was originally shown to attenuate gastric mucosal lesions but the controversy exists in the literature as to whether melatonin derived from the pineal gland, considered as the major s...

Peptic ulcer is the erosion in lining of stomach or duodenum. The word ‘Peptic’ refers to pepsin, a stomach enzyme that break downs proteins. Peptic ulcer located in the stomach is called gastric ulcer. Normally the linings of the stomach and small intestine have protection against the irritating acid produced in stomach. For a variety of reasons, the protective mechanism may become faulty, lea...

BACKGROUND & OBJECTIVES Most of the non-steroidal anti-inflammatory drugs (NSAIDs) including aspirin cause gastric ulcer. In order to study the gastroprotective effect of Cissus quadrangularis extract (CQE), this study was undertaken on aspirin-induced ulcerogenesis in pyloric ligated (ASP-PL) model in rats. METHODS To assess the possible antiulcer effect of CQE, lesion index, gastric secreti...

ABSTRACT Introduction: Formation of gastric ulcer is a multifactorial process so that vascular changes, mucous secretion, gastric acid and gastrointestinal tract mucous biochemistry are involved in gastric ulcers. Despite therapeutic properties, ibuprofen as a non-steroidal anti-inflammatory drug (NSAID) can cause mucosal lesions in the stomach. In this study, the effect of Matri...