The possibility of gene-environment interaction can be exploited to identify genetic variants associated with disease using a joint test of genetic main effect and gene-environment interaction. We consider how exposure misclassification and dependence between the true exposure E and the tested genetic variant G affect this joint test in absolute terms and relative to three other tests: the marg...

Background: The traditional methods of studying the gene-environment interactions need a control group. However, the selection of an appropriate control group has been associated with problems. Therefore, new methods, such as case-only design, have been created to study such interactions. The objective of this study was to compare the case-only and case-control designs using data from patients ...

genetic parameters were estimated for somatic cell score (scs) in dairy cattle of iran using test day records. the records of first lactation were extracted from the database of national animal breeding center for cows calved between 2001 and 2010. data included 222923 test-day records, obtained from 29668 animals distributed in 100 different herds. estimates were carried out through gibbs samp...

tomato as a highly nutritious vegetable crop is widely grown in the world. hybrid seed is preferably used for tomato production. identification of superior hybrid combination is one of the most important steps in the hybrid breeding programs. breeding of high yielding hybrids is expensive and involves testing large numbers of hybrid combinations in multi-environment trials. successful predictio...

Suppose that many polymorphic sites have been identified and genotyped in a region showing strong linkage with a trait. A key question of interest is which site (or combination of sites) in the region influences susceptibility to the trait. We have developed a novel statistical approach to this problem, in the context of qualitative-trait mapping, in which we use linkage data to identify the po...

The use of a reference control panel in genome-wide association studies is an interesting solution to the problem of how to reduce costs. In such designs, data on relevant environmental factors are usually collected only in cases, making it more difficult to deal with potential gene-environment interactions when testing for genetic association. However, under certain circumstances, neglecting a...