BACKGROUND Kynurenine aminotransferase 3 (KAT3) catalyzes the transamination of Kynurenine to kynurenic acid, and is identical to cysteine conjugate beta-lyase 2 (CCBL2) and glutamine transaminase L (GTL). GTL was previously purified from the rat liver and considered as a liver type glutamine transaminase. However, because of the substrate overlap and high sequence similarity of KAT3 and KAT1, ...

We reported previously that a protein tyrosine phosphatase (PTP) activity is associated with the immunoprecipitated hepatocyte growth factor (HGF) receptor, also known as Met. The activity increased reversibly when Met was stimulated by HGF and decreased when Met was inactivated by PMA. To identify the PTP-binding region, we used deletion mutants of the receptor beta-subunit. The PTP activity d...

BACKGROUND Studying the uptake of 2-deoxy glucose (2-DG) analogs such as 2-Deoxy-2-[18F] fluoroglucose (FDG) is a common approach to identify and monitor malignancies and more recently chronic inflammation. While pancreatitis is a common cause for false positive results in human studies on pancreatic cancer using FDG, the relevance of these findings to acute pancreatitis (AP) is unknown. FDG ha...

The presented paper aims to study the influence of mineral diesel fuel and synthetic Gas-To-Liquid (GTL) on injection process, flow conditions, cavitation formation in a modern common-rail injector. First, characteristics was studied experimentally using an system test bench, numerically one-dimensional computational program. Afterward, properties internal inside injector considered as multipha...

Improving the dielectric properties of liquid-insulating materials is a current problem in research into insulation system power transformer. Modern optimization insulating liquids involves potential use unique synthetic esters enriched with nanoparticles. This study presents results response liquefied gas-based (GTL) during accelerated thermal aging. The relaxation spectroscopy method was used...

The interest in Gas-to-Liquid technology (GTL) is growing worldwide because it involves a two-step indirect conversion of natural gas to higher hydrocarbons ranging from Liquefied Petroleum Gas (LPG) paraffin wax. GTL makes possible obtain clean diesel, naphtha, lubes, olefins, and other industrially important organics gas. This article brief review discussing the state-of-the-art GTL, includin...

Transfer learning proves to be effective for leveraging labeled data in the source domain build an accurate classifier target domain. The basic assumption behind transfer is that involved domains share some common latent factors. Previous methods usually explore these factors by optimizing two separate objective functions, i.e., either maximizing empirical likelihood, or preserving geometric st...

Purpose: Heat shock protein-90 (HSP-90), a molecular chaperone required by numerous oncogenic kinases [e.g., HER-2, epidermal growth factor receptor (EGFR), Raf-1, v-Src, and AKT] for conformational stability, has attracted wide interest as a novel target for cancer therapy. HSP-90 inhibition induces degradation of HSP-90 client proteins, leading to a combinatorial inhibition of multiple oncoge...