Stress induced analgesia (SIA) is well known, but the reverse phenomenon, hyperalgesia is poorly documented. This study investigated the role of the histaminergic system in restraint stress hyperalgesia in rats, using thermal stimulation method (hot plate and tail flick tests). Paw licking and tail withdrawal latencies were taken before and after restraint for about one hour. Significant decrea...

Proton pump inhibitor (PPI) use is associated with an increased risk of acute kidney injury (AKI), incident chronic kidney disease (CKD), and progression to end-stage renal disease (ESRD). PPI-associated CKD is presumed to be mediated by intervening AKI. However, whether PPI use is associated with an increased risk of chronic renal outcomes in the absence of intervening AKI is unknown. To evalu...

Selective antihistamine receptor type 2 blockers are widely used for treatment of peptic ulcer, these drugs are famotidine,cimetidine,nizatidine and ranitidine and because many nonantibiot ics agents have antibacterial activity so this study aimed to evaluate the antibacterial effects of selective H2 blockers. Tewnty two of bacterial strains were slected 5 Staphylococcus aureus,5 Escherichia co...

OBJECTIVE We sought to determine if an association exists between the use of histamine-2 receptor (H2) blockers and the incidence of necrotizing enterocolitis (NEC) in infants of 401 to 1500 g in birth weight. STUDY DESIGN Data from the National Institute of Child Health and Human Development Neonatal Research Network very low birth weight (401-1500 g) registry from September 1998 to December...

The incidence of peptic ulcer disease (PUD) has steadily declined with the advent H2 blockers and proton pump inhibitors (PPIs). combined use PPIs endoscopic treatment further decreased need for emergency surgeries. Perforated ulcers are a rare cause abdominal pain, may not even be considered when patient presents right lower quadrant (RLQ) pain. In this article we report case 50-year lady, who...

The prevalence of GERD in most European countries and the Russian Federation is at level 15–20%. Hydrochloric acid plays a significant sometimes major role damage to mucosa upper gastrointestinal tract (GIT) patients with various acid-related diseases. Despite presence classes drugs that reduce damaging effect hydro-chloric on mucous membrane tract, diseases continues be an urgent medical probl...

The eye is a target organ for the action of several topical or systemic drugs. The aim of the present study is to analyze the differences in reactivity between the iris and conjunctiva vessels after the topical administration of histamine and histamine receptor blockers respectively. Using a novel non-invasive technique for the quantification of the vascular diameters in the eye vessels, the re...

The Zollinger-Ellison syndrome, which is due to the secretion of gastrin from non-beta islet cell tumors of the pancreas, results in gastric hypersecretion and severe peptic ulcer disease. In the 1970s H2 blockers became the mainstay of therapy. More recent evidence indicates that early surgical intervention aimed at tumor extirpation results in improved outcome. The purpose of this paper is to...