The effects of histones on the enzymatic phosphorylation of nuclear phosphoproteins have been extensively studied in vitro. Histones cause a 5to Io-fold increase in the rate and extent of phosphorylation of nuclear phosphoprotein, with the lysinerich histones being the most effective at stimulation. Evidence suggests that the histones are not being phosphorylated themselves, but rather act to m...

Core histones have been isolated from Schizosaccharomyces pombe and compared electrophoretically to core histones from Saccharomyces cerevisiae and rat liver. The molecular masses of all cognate histones examined were found to be very similar as determined by SDS gel electrophoresis. Histones H3, H2A and H2B from Sch. pombe migrated almost identically to their respective counterparts from S. ce...

Alcohol use disorder (AUD) has a complex, multifactorial etiology involving dysregulation across several brain regions and peripheral organs. Acute chronic alcohol consumption cause epigenetic modifications in these systems, which underlie changes gene expression subsequently, the emergence of pathophysiological phenotypes associated with AUD. One such mechanism is methylation, can occur on DNA...

It has been reported that histones inhibit DNAdependent RNA synthesis in vitro (5, 15) and these results have been taken as support of the hypothesis (34) that histones function as regulators of gene activity in vivo. One necessary correlate of this hypothesis is that different cell types contain different amounts and/or different kinds of histones or that the histone-DNA interactions differ in...

The complex genomic structure of eukaryotic cells is primarily achieved by the binding DNA to histones. Different members histone families form a with and, as nucleosome, constitute functional unit chromatin. In addition their structural functionality, histones are also involved in other molecular mechanisms, such damage recognition and repair. A very important factor management H2A.X. phosphor...

The development of resistance to plant pathogens is determined by the presence genes and regulation their activity due phytohormones, nuclear pore complex, epigenetic modifications at post-transcriptional post-translational levels DNA histones, respectively. Changes in gene expression such can be inherited generations contribute selection resistant plants populations.The complex composed nucleo...

The importance of histone acetylation, phosphorylation, and methylation in transcription and other DNA-mediated processes is now well established. Histones are also ubiquitylated, but in contrast to the majority of ubiquitylated proteins, ubiquitylated histones are not generally targeted for degradation and may play roles similar to those of other histone modifications. Antibodies against acety...

BACKGROUND Extensive DNA damage leads to apoptosis. Histones play a central role in DNA damage sensing and may mediate signals of genotoxic damage to cytosolic effectors including mitochondria. METHODOLOGY/PRINCIPAL FINDINGS We have investigated the effects of histones on mitochondrial function and membrane integrity. We demonstrate that both linker histone H1 and core histones H2A, H2B, H3, ...