BACKGROUND Intestinal microbiota are critical determinants of obesity and metabolic disease risk. In previous work, we showed that deletion of the cytoplasmic lipid droplet (CLD) protein perilipin-2 (Plin2) modulates gut microbial community structure and abrogates long-term deleterious effects of a high-fat (HF) diet in mice. However, the impact of Plin2 on microbiome function is unknown. RES...

The human oro-gastrointestinal (GI) tract is a complex system, consisting of oral cavity, pharynx, oesophagus, stomach, small intestine, large intestine, rectum and anus, which all together with the accessory digestive organs constitute the digestive system. The function of the digestive system is to break down dietary constituents into small molecules and then absorb these for subsequent distr...

the relationship between female oviposition preference and offspring performance is a key area of study on the evolution of host specificity. this study investigates host prefer-ence of the polyphagous hover fly syrphus ribesii (diptera: syrphidae) and compares it with some components of its offspring`s performance. females and offspring were tested on six naturally used aphid hosts (blackberry...

S U M M A R Y Rabbits fed cholesteroland oil-supplemented diet were carefully paired for equality of plasma cholesterol concentration during the feeding period and a subsequent 30 days of normal diet. The normal diet was continued and one of each pair of rabbits was then subjected to intravenous infusion of mixed phosphatides of animal or soybean origin twice weekly for an average of 11 infusi...

Cancer cachexia induces host protein wastage but the mechanisms are poorly understood. Branched-chain amino acids play a regulatory role in the modulation of both protein synthesis and degradation in host tissues. Leucine, an important amino acid in skeletal muscle, is higher oxidized in tumor-bearing animals. A leucine-supplemented diet was used to analyze the effects of Walker 256 tumor growt...

Polyphenol extracts from red raspberry (RR) whole fruit or pulp, but not seed, attenuate high-fat (HF) diet-induced obesity in mice. Because host metabolism is linked to the microbiota, we investigated effects of polyphenols RR fruit, and seed on microbiome. significantly decreased abundance specific taxa that were increased during HF feeding relative a low-fat diet, including Ruminococcus an u...

We propose a new mechanism based on sexual selection to explain the evolution of diet breadth in insects. More specifically, we show that mate choice in females for certain diet-derived male pheromones can be exploited by maternal effect genes that preferentially place offspring on a specific host plant, resulting in specialization. Our analytical model also suggests that the process is more li...

The gut microbiome and daily feeding/fasting cycle influence host metabolism and contribute to obesity and metabolic diseases. However, fundamental characteristics of this relationship between the feeding/fasting cycle and the gut microbiome are unknown. Our studies show that the gut microbiome is highly dynamic, exhibiting daily cyclical fluctuations in composition. Diet-induced obesity dampen...

Over the past decade, the gut microbiota has emerged as an essential mediator in the pathophysiology of obesity and related metabolic disorders. In this context, the reciprocal interactions of the gut microbiota structure and their metabolite profiles with host metabolism predisposing to a range of pathological conditions (e.g., insulin resistance) related to energy homeostasis have been increa...

Obesity has reached epidemic proportions and is associated with chronic-low-grade inflammation metabolic morbidities. Energy-dense diets a sedentary lifestyle are determinants of obesity. The gut microbiome novel biological factor involved in obesity via interactions the host diet. act as synergistic force protecting or aggravating effects diet on phenotype. role regulation intestinal systemic ...