The primary purpose of this study was to process partially hydrolyzed PVOH grades (degree of hydroxylation (DH): 33-88%) via HME and to evaluate them as carrier for oral immediate release dosage forms in order to improve the release rate of poorly water soluble drugs (i.e., HCT and CEL) via the formulation of solid dispersions. PVOH grades (DH >70%) were able to solubilize HCT and CEL up to 15%...

The present study aimed to evaluate the effect of degassing on an extrusion process, with respect to extrudate quality and drug release properties. Processed formulations were extruded with and without a degassing vent port at various locations along the barrel. All the experiments were performed under constant processing temperature, feeding rate, and screw speed. During the extrusion process,...

Al-SiC composites were successfully produced with improved mechanical properties. Effect of SiC content, its particles size and shaping method were investigated. Three shaping methods of conventional powder metallurgy (PM), hot press (HP) and hot extrusion (EX) were used. The hardness of the samples was measured by Vickers method. Tensile and compression tests were performed for the characteriz...

Over the decades with outcome of industrial compliance, manufacturing process, formulation and development, Hot Melt Extrusion (HME) has also expanded acceptance. As a result adaptability, it developed itself in wide range as part pharmaceutical research development. New drug entities face failures or delays during including poor biopharmaceutical properties, toxicities lack efficacy. To overco...

The aim of this study was to develop a multilayer (core/coat) dosage form via co-extrusion, the core providing sustained drug release and the coat immediate drug release. In this study polymers were selected which can be combined in a co-extruded dosage form. Several thermoplastic polymers were hot-melt extruded and evaluated for processability and macroscopic properties (surface smoothness, di...