نتایج جستجو برای: il 13
تعداد نتایج: 462785 فیلتر نتایج به سال:
Lebrikizumab (lebri) is a novel, monoclonal antibody that selectively targets IL-13 and prevents formation of the receptor alpha 1 (Rα1)/IL-4 (Rα) heterodimer signaling complex. A previous crystal structure report showed lebri does not interfere with binding to Rα2 decoy receptor. In contrast, other antibodies tralokinumab cendakimab had been reported inhibit both IL-13Rα1 IL-13Rα2. We wanted i...
BACKGROUND IL-13 is a critical mediator of allergic asthma and associated airway hyperresponsiveness. IL-13 acts through a receptor complex comprised of IL-13Ralpha1 and IL-4Ralpha subunits with subsequent activation of signal transducer and activator of transcription 6 (STAT6). The IL-13Ralpha2 receptor may act as a decoy receptor. In human airway smooth muscle (HASM) cells, IL-13 enhances cel...
Background& Objective: Host resistance towards Leishmania infection is mediated by cellular immune responses leading to macrophage activation and parasite killing. According to the important role of IL-13 in the defense against visceral leishmaniasis (VL) and the known effect of the IL-13 gene polymorphisms on its production, the aim of this study was to investigate the probable relationship be...
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