the biological application of nanoparticles (nps) is a rapidly developing area of nanotechnology that raises new possibilities in the treatment of human cancers. the cytotoxicity was evaluated by mtt and ldh assays. the apoptotic effect of free icd-85 and icd-85 nps on hela cells was assessed using caspase-8 colorimetric assay. the mtt assay showed that icd-85 nps could enhance the in-vitro cyt...

background to current knowledge, different oocyte's recovery method and various seasons have profound impact on in vitro embryo production (ivep). objectives the aim of this study was to define an efficient recovery method for oocytes harvesting from slaughterhouse material in different seasons, and their effects on ivep yield. materials and methods ovaries from slaughtered ewes in breeding sea...

A possible role for C1q in antibody-dependent granulocyte-mediated killing of nonphagocytosable targets was investigated utilizing IgG-dependent granulocyte cytotoxicity directed against microfilariae of Dirofilaria immitis. Granulocyte-mediated killing of microfilariae is enhanced by addition of fresh serum. Lack of C4 did not significantly reduce the observed increase in cytotoxicity. The add...

The crystallizable fragment (Fc) of the immunoglobulin class G (IgG) is a very attractive scaffold for the design of novel therapeutics due to its quality of uniting all essential antibody functions. This article reviews the functionalization of this homodimeric glycoprotein by diversification of structural loops of CH3 domains for the design of Fcabs, i.e. antigen-binding Fc proteins. It repor...

The great variability and high glycosylation of gp120 poses a great challenge for the design of a functional immune therapy. The binding region of the CD4 receptor to gp120, however, is well conserved and may constitute a target to limit viral entry and infectivity. Our strategy consists in using a preexisting pool of natural antibodies directed toward the gal(alpha1,3)gal disaccharide and to r...

A series of novel bis-1,3,4-oxadizaoles were synthesized by oxidative cyclisation of respective Schiff bases derived from dicarbohydrazide using ceric ammonium nitrate (CAN) as catalyst. The synthesized compounds were screened for in vitro antibacterial activity against Staphylococcus aureus (MTCC 87), Escherichia coli (MTCC 46) and antifungal activity against Candida albicans (NCIM 3471) by tw...

objective: resin cements, regardless of their biocompatibility, have been widely used in restorative dentistry during the recent years. these cements contain hydroxy ethyl methacrylate (hema) molecules which are claimed to penetrate into dentinal tubules and may affect dental pulp. since tooth preparation for metal ceramic restorations involves a large surface of the tooth, cytotoxicity of thes...

abstract: background and aim: resin cements are used widely in restorative dentistry regardless of their biocompatibility. the aim of this study was to compare the cytotoxicity of two categories of dental cements consisting of three chemically set cements (fuji i, fuji plus and harvard) and two dual curing cements (biscem and duo-link) by use of mtt assay. materials and methods: in this experim...