introduction: indomethacin increases generation of mitochondrial reactive oxygen species (ros) which have a crucial role in the indomethacin-induced gastric ulcer. coenzyme q10 has an antioxidant activity on mitochondria and cell membranes and protects lipids from oxidation and is essential for stabilizing biological membranes. superoxide dismutase (sod) acts as one of the defense mechanisms ag...

background: testosterone and its metabolites have important roles in learning and memory. the current study has conducted to assess the effect of pre-training, post-training and pre-probe trial intrahippocampal ca1 administration of 3 alpha-anderostanediol (one of the metabolites of testosterone) and indomethacin (as 3 alpha-hydroxysteroid dehydrogenase enzyme blocker) on acquisition, consolida...

Introduction: Indomethacin increases generation of mitochondrial reactive oxygen species (ROS) which have a crucial role in the indomethacin-induced gastric ulcer. Coenzyme Q10 has an antioxidant activity on mitochondria and cell membranes and protects lipids from oxidation and is essential for stabilizing biological membranes. Superoxide dismutase (SOD) acts as one of the defense mechanisms ag...

services companies attempt to promote their delivered services to customers and achieve a stable competitive advantage. for achieving this goal, marketing and hr scholars jointly propose application of internal marketing (im) principles and instruments. although im is a 30 years old concept in management, but it's measurement and application method have faced with different structural and ...

A simple equilibrium restriction identifies time-varying components of expected returns. Using data from the Fama and French threeand fivefactor models and momentum, we use this restriction to predict factor returns out of sample. We derive a policy for timing exposures to these components and find the modified portfolio generates returns with higher out-of-sample Sharpe ratios than the underly...

Introduction: It is a well-known phenomenon that nonsteroidal anti-inflammatory drugs cause gastric mucosal damage. Amlodipine third generation dihydropyridine-type calcium channel blocker; it can inhibit inflammatory cytokines and enhance antioxidant defenses. N-acetylcysteine act both as precursor of reduced glutathione direct ROS scavenger. Moreover, has been purported to have properties.&#x...

BACKGROUND/AIMS We have shown that indomethacin has the potential to activate Ca2+/ calmodulin-dependent protein kinase II (CaMKII), regardless of cyclooxygenase (COX) inhibition. To understand the underlying mechanism, the present study investigated the effect of indomethacin on protein phosphatases such as protein phosphatase 1 (PP1), protein phosphatase 2A (PP2A), and protein tyrosine phosph...