introduction: the prevalence of allergic airway diseases has dramatically increased in recent years all over the world. murine models of allergic airway inflammation have provided helpful information about treatment and cellular and molecular mechanisms of the disease. previous published works using murine models to investigate latex allergy did not introduce a complete characteristic eosinophi...

Abstract The subcutaneous air pouch is an in vivo model that can be used to study the components of acute and chronic inflammation, resolution inflammatory response, oxidative stress potential therapeutic targets for treating inflammation. Injection irritants into rats or mice induces response quantified by volume exudate produced, infiltration cells, release mediators. presented this article h...

objective(s) air pouch is a well-established inflammatory model in which fluid extravasations; leukocyte migration, angiogenesis and other parameters involved in the inflammatory response can be measured. in this study, the influence of gender on inflammatory parameters has been examined in the air pouch model. materials and methods to induce air pouch, adult male and female wistar rats were an...

spinal cord injury (sci) is a crucial complication that results in neurons degeneration. the sci lead to triggering of secondary complications such as inflammation that in turn has a key role in neurodegeneration development. the previous studies showed that tnf-α and inos genes expression increased significantly after sci. as a consequence, these genes overexpression intensify the inflammation...

one of the important reasons for death among the worldwide’s population is trauma which is injury or damage to a biological organism caused by physical harm from an external source. after trauma, the immune system and the early inflammatory immune response activation lead to massive injury. trauma causes activation of nearly all components of the immune system; it also activates the neuroendocr...

macrophages accumulate in poorly vascularised and hypoxic sites including solid tumours, wounds and sites of infection and inflammation where they can be exposed to low levels of oxygen for long periods. up to date, different studies have shown that a number of transcription factors are activated by hypoxia which in turn activate a broad array of mitogenic, pro-invasive, pro-angiogenic, and pro...