Beyond its critical function in calcium homeostasis, vitamin D has recently been found to play an important role in the modulation of the immune/inflammation system via regulating the production of inflammatory cytokines and inhibiting the proliferation of proinflammatory cells, both of which are crucial for the pathogenesis of inflammatory diseases. Several studies have associated lower vitami...

OBJECTIVE Refractory status epilepticus is one of the most life-threatening neurological emergencies and is characterized by high morbidity and mortality. Additionally, the use of anti-inflammatory drugs during this period is very controversial. Thus, this study has been designed to analyze the effect of a low dose of indomethacin (a COX inhibitor) on the expression of inflammatory molecules. ...

BACKGROUND Subjective social status (captured by the MacArthur Scale of Subjective Social Status) is in many cases a stronger predictor of health outcomes than objective socioeconomic status (SES). PURPOSE The study aims to test whether implicit beliefs about social class moderate the relationship between subjective social status and inflammation. METHODS We measured implicit social class b...

Objective: The overweight-related health problems among adolescents are obvious. Resistance training is recognized as a safe and efficacious exercise modality to have health-promoting effects in overweight adolescents. This study aimed to assess the efficacy of circuit resistance training (CRT) in improving inflammatory status, insulin resistance and body composition in overweight male adolesce...

Introduction: Oxidative stress and inflammation could occur after major gastrointestinal surgeries. Selenium is a micronutrient with anti-inflammatory and antioxidant properties, which could improve the inflammatory markers in the children admitted to the intensive care unit (ICU) after gastrointestinal surgeries. Due to the lack of evidence on the potential effects of high-dos...

Since their isolation until implantation, pancreatic islets suffer a major stress leading to the activation of inflammatory reactions. The maintenance of controlled inflammation is essential to preserve survival and function of the graft. Identification and targeting of pathway(s) implicated in post-transplant detrimental inflammatory events, is mandatory to improve islet transplantation succes...

BACKGROUND Sedentary behaviour, obesity and insulin resistance are associated with pro-inflammatory status. Limited data on whether physical activity modulates inflammatory status and counteracts obesity and insulin resistance associated low-grade inflammation exist. Our objective was to investigate associations between objectively measured physical activity and inflammatory status, and specifi...

Chronic obstructive pulmonary disease (COPD) is a condition associated with inflammation in lungs and airways. The impacts of inflammatory process is not limited to respiratory system but extend to extrapulmonary organs with resultant complications involving endocrine, metabolic and cardiovascular systems. The extent and severity of inflammation may be partly estimated by serum measurement of s...

Changes in maternal innate immunity during healthy human pregnancy are not well understood. Whether basal immune status in vivo is largely unaffected by pregnancy, is constitutively biased towards an inflammatory phenotype (transiently enhancing host defense) or exhibits anti-inflammatory bias (reducing potential responsiveness to the fetus) is unclear. Here, in a longitudinal study of healthy ...