Interferon regulatory factor (IRF)-1 is an immunomodulatory transcription factor that functions downstream of pathogen recognition receptor signaling and has been implicated as a regulator of type I interferon (IFN)-αβ expression and the immune response to virus infections. However, this role for IRF-1 remains controversial because altered type I IFN responses have not been systemically observe...

Toll-like receptors (TLRs) play a key role in the activation of innate immune cells, in which their engagement leads to production of cytokines and co-stimulatory molecules. TLRs signaling requires recruitment of toll/IL-1R (TIR) domain-containing adaptors, such as MyD88 and/or TRIF, and leads to activation of several transcription factors, such as NF-κB, the AP1 complex, and various members of...

background: prognosis of small intestine artesia, the most common agents causing intestinal obstruction in neonates, has improved in last decades. some variable such as weight change, type of feeding, post operation oral feeding starting time, and adequacy of energy and protein intake can change patients clinical outcomes. we performed a retrospective study to evaluate all neonates with small i...

In this study, we describe the specific features of near-field distribution a uniformly illuminated aperture. An analytical method based on physical optics in time domain is used to calculate field intensity. The primitive impulse response function makes it possible antenna. difference amplitudes fields during observation point shift along X and Y coordinate axes can reach up 13% their maximum ...

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An increasing number of researchers are studying discourse in order to understand classroom instruction. Based on social linguistics and activity theory, researchers have derived frameworks for breaking down discussion and identifying its structure and composition. These frameworks can be fairly easily utilized to analyze class instruction, because it is typically highly facilitated and/or well...

Interferon regulatory factor 1 (IRF-1) and IRF-8, also known as interferon consensus sequence binding protein (ICSBP), are important regulators of macrophage differentiation and function. These factors exert their activities through the formation of heterocomplexes. As such, they are coactivators of various interferon-inducible genes in macrophages. To gain better insights into the involvement ...

This paper investigates learner-initiated responses to English language teachers’ referential questions and learner initiatives after teachers’ feedback moves in meaning-focused question-answer sequences to analyze how interactional practices of language teachers, their initiation and feedback moves, facilitate learner initiatives. Classroom discourse research has largely neglected learner init...

IFN-regulatory factor (IRF)-4 is a member of the IRF family of transcription factors expressed in lymphocytes and macrophages. The previous studies using mice deficient in the IRF-4 gene showed profound defects in function of both B and T cells. To further investigate the role of IRF-4 in CD4(+) T cell function, IRF-4(-/-) mice were challenged with the intracellular pathogen Leishmania major. T...