BACKGROUND Cancer cells have increased levels of transferrin receptor and lower levels of ferritin, an iron deficient phenotype that has led to the use of iron chelators to further deplete cells of iron and limit cancer cell growth. As cancer cells also have increased reactive oxygen species (ROS) we hypothesized that a contrarian approach of enhancing iron entry would allow for further increas...

Iron is the fourth most abundant element on Earth and is essential for almost all living organisms. However, it is not accessible to cells in every environment. Ferric iron solubility is low at physiological pH, and in aerobic environments, ferrous iron is highly toxic. Thus, iron is not free but bound to proteins [Clarke et al., 2001; Taylor and Kelly, 2010]. In complex organisms, the majority...

A novel and unprecedented formation of η(4)-(vinylketene)iron complexes from η(4)-(diene)iron complexes is described herein. Treatment of η(4)-(diene)iron complexes with a Lewis acid such as GaCl3 or AlCl3 in the presence of aromatic compounds under a CO atmosphere affords η(4)-(vinylketene)iron complexes via electrophilic aromatic substitution.

Knowledge of the hardness of abrasive particles that are used in polishing is a key to the fundamental understanding of the mechanisms of material removal. The magnetorheological-finishing process uses both magnetic and nonmagnetic abrasive particles during polishing. The nanohardnesses of the micrometer-sized magnetic carbonyl iron and nonmagnetic abrasive particles have been measured successf...

Research this year in the laboratory and field continued to show that the bactericidal action of copper compounds could be greatly increased by amending them with iron. There are at least three different mechanisms which cause the increased efficacy: 1) When soluble iron is added to fixed coppers at amounts ranging from 10 to 100 ppm, the ferric iron interacts synergistically with the copper io...

In Arabidopsis roots, the transcription factor MYB72 plays a dual role in the onset of rhizobacteria-induced systemic resistance (ISR) and plant survival under conditions of limited iron availability. Previously, it was shown that MYB72 coordinates the expression of a gene module that promotes synthesis and excretion of iron-mobilizing phenolic compounds in the rhizosphere, a process that is in...

The antimalaria effect of iron chelators is attributed to their interaction with a labile iron pool within parasitised erythrocytes, and it was postulated that increased affinity to iron as well as increased lipophilicity may improve antimalarial activity. In the present study we have examined the antimalarial effect of 3-hydroxypyridin-4-ones, a family of bidentate orally effective iron chelat...

The effect of foliar spray of different chemicals on the sorghum cultivar KH-333 in four type nutrient medium viz; normal pH, high pH, high bicarbonate (10 mM) and, high pH (8.0) &high bicarbonate (10 mM) on biochemical parameters and the recovery of iron chlorosis in fodder sorghum was examined. The effect of iron chlorosis and sulphydryl compounds on the antioxidant enzymes and active iron co...