BACKGROUND There is a significant clinical need for effective treatment of iron deficiency. A number of compounds that can be administered intravenously have been developed. This study examines how the compounds are handled by macrophages and their relative potential to provoke oxidative stress. METHODS Human kidney (HK-2) cells, rat peritoneal macrophages and renal cortical homogenates were ...

Iron deficiency is one of the most prevalent nutritional problems in the world. Iron compounds are sed for the prevention and treatment of this deficiency. A double-blind randomized crossover study ith 12 volunteers was carried out to compare the effect of three iron compounds, ferrous glycine helate (GLY), ferric EDTA (EDTA), and ferrous sulfate (FS) on serum iron, and to examine serial erum i...

This work describes a novel method for the detection, identification and mapping of anomalous iron compounds in mammalian brain tissue using X-ray absorption spectroscopy. We have located and identified individual iron anomalies in an avian tissue model associated with ferritin, biogenic magnetite and haemoglobin with a pixel resolution of less than 5 microm. This technique represents a breakth...

Iron is stored in tissues as ferritin and hemosiderin. These compounds are increased in a state of iron excess and become depleted with iron deficiency (2). Both may be considered to represent iron reserves which may be mobilized when needed. The functional relationship between these two compounds has been a matter of speculation. It has been suggested that the ferritin fraction represents more...

Eight organo-iron ferrocene derivatives and arenocenium salts were prepared and evaluated by "in vitro" assay against one strain of Trypanosoma cruzi (Y). Six of the eight organo-iron compounds assayed, piperazinium diferrocenoate 1, eta(6)-(o-xylene)-eta(5)-(cyclopentadienyl) Iron(II) hexafluorophosphate 3, eta(6)-(mesitylene)-eta(5)-(cyclopentadienyl) iron(II) hexafluorphosphate 5, eta(6)-(du...

a series of 3- hydroxypyridin -4-one derivatives (hpos) as bidentate iron (iii) chelating agents were synthesized from 3- hydroxypyran -4-ones (maltol and ethyl maltol) in three steps through protection of hydroxyl group . the protected compounds were then reacted with suitable primary amines to give benzylated pyridinones . finally, the benzyl group was removed by catalytic hydrogenation to pr...