Renal ischemia and reperfusion during aortic and renal transplant surgery result in ischemic-reperfusion injury. Ischemic preconditioning and adenosine infusion before ischemia protect against ischemic-reperfusion injury in cardiac and skeletal muscle, but these protective phenomena have not been demonstrated in the kidney. Rats were randomized to sham operation, 45-min renal ischemia, ischemic...

Introduction: In the current study, protective effect of natural honey applied during ischemia/reperfusion (I/R) was studied on infarct size in ischemic heartheart. Methods: Ischemic hearthearts (n=8 per group) were mounted on a Langendorff apparatus at constant pressure then subjected to 30 min regional ischemia followed by 120 min reperfusion. In control group, the hearts were perfused by ...

OBJECTIVES Remote ischemic perconditioning is the newest technique used to lessen ischemia/reperfusion injury. However, its effect in hypertensive animals has not been investigated. This study aimed to examine the effect of remote ischemic perconditioning in spontaneously hypertensive rats and determine whether chronic treatment with Olmesartan could influence the effect of remote ischemic perc...

Introduction: Nitric oxide seems to play a dual role in ischemia/reperfusion injury. Few studies have investigated whether it exacerbates or improves brain edema. In the present study, we inhibited the activity of nitric oxide synthase by L-NAME and evaluated the cerebral infarct volume, tissue swelling and brain edema, alongside the measurement of blood flow of the ischemic region. Methods...

Background: Central renin angiotensin system has an important role on the cerebral microcirculation and metabolism. Our previous work showed that inhibition of angiotensin converting enzyme (ACE) activity prior to induction of ischemia protected the brain from severe ischemia/reperfusion (I/R) injuries. This study evaluated the impacts of post-ischemic inhibition of ACE, enalapril, on brain inf...

The aim of the study is to analyze current views concerning interrelations between state intestinal microbiota and course ischemic-reperfusion brain injury. 
 Conclusion. Literary data are indicative disputable scientific opinions existing nowadays role dysbacteriosis (neuroprotective or neurodegenerative) in ischemic injuries. Meanwhile, studies common evidenced disturbances T-cell homeos...

introduction: development of brain edema following focal cerebral ischemia exacerbates primary ischemic injury. blood brain barrier (bbb) opening is an important part of edema named as vasogenic brain edema. in this study, quantitative alterations of bbb permeability is experimentally evaluated using transient focal cerebral ischemia in the rat. methods: two groups of male rats (ischemic and sh...

objective(s): the alteration of glucose transporters is closely related with the pathogenesis of brain edema. we compared neuronal damage/death in the hippocampus between adult and young gerbils following transient cerebral ischemia/reperfusion and changes of glucose transporter-1(glut-1)-immunoreactive microvessels in their ischemic hippocampal ca1 region. materials and methods: transient cere...

Following acute myocardial infarction (MI), limitation of infarct size is central to long-term outcome (1). Successful reperfusion results in smaller infarct size and a marked reduction in mortality (1,2). However, following fibrinolytic therapy, ischemic myocardial injury continues during the process of clot lysis. Although reperfusion arrests the acute ischemic injury, it may cause further in...

BACKGROUND Nonlethal ischemia and reperfusion reduce ischemia-reperfusion-induced cell death, a phenomenon called ischemic preconditioning. In animal models, this potent endogenous protection is mimicked in vivo by administration of adenosine. In humans, exploitation of ischemic preconditioning is hindered by the lack of an appropriate in vivo model to study this phenomenon. To solve this probl...