In previous studies we have shown that sulfatide (galactosylceramide-3-O-sulfate), in various species, is present in the insulin-producing cells in pancreatic islets of Langerhans. In this study the synthesis of sulfatide in the islets has been investigated by pulse chase labeling at varying glucose levels and in the presence or absence of the glycosphingolipid synthesis inhibitory agents, Bref...

I N PATIENTS with type I diabetes. insulin production by pancreatic islets declines until severnl years after onset, and the majority have no demonstrable endogenous insulin secretion due to relentless autoimmune destruction of insulin-producing B cells. Before 1990, the lack of any successful islet cell transplants in humans was frustrating. With new developments in the techniques used to isol...

King, A. 2001. Evaluation of Alginate Microcapsules for Use in Transplantation of Islets of Langerhans. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1072. 43 pp. Uppsala. ISBN 91554-5113-6 Transplantation of islets of Langerhans is a potential treatment of type 1 diabetes that aims to restore normal glucose homeostasis. Microencap...