Abstract The evolutionary process involved the suffering of quadrillions sentient beings over millions years. I argue that when we take this into account, then it is likely first humans appeared, world was already at an enormous axiological deficit, and even on favorable assumptions about humanity, doubtful have overturned deficit or ever will. Even if there’s no such can overturn it, remains c...

W e live in a constantly changing environment. Although some changes are natural and therefore beyond our control, there is no question that many anthropogenic activities have dramatically altered our planet. The ‘‘human footprint’’ is now discernable around the globe, so much so that Crutzen (1) proposed a new geological epoch (the Anthropocene) to delineate the recent human-dominated era of E...

Huntington disease (HD) is an autosomal-dominant, incurable, progressive disorder that manifests with chorea and behavioral and cognitive impairment. The disease usually occurs during the fourth or fifth decade of life; however, it may present at any age. Clinical suspicion is confirmed by genetic testing. Death occurs, on average, 15 to 20 years after the onset of symptoms. Here we report abou...