Patients and methods 34 patients were selected on clinical grounds by members of the French reference center for autoinflammatory diseases (CeReMAI). 9 of them were considered positive control samples as they had previously known variants (by Sanger sequencing) and were run in parallel for methodological validation. A custom panel of 108kb was designed to capture the genomic regions of interest...

U.S. President's Emergency Plan for AIDS Relief (PEPFAR) and the United States Agency for International Development (USAID) under the Cooperative Agreement Strengthening High Impact Interventions for an AIDS-free Generation (AIDSFree), number AID-OAA-A-14-00046. AIDSFree is implemented by JSI Research & Training Institute, Inc. with partners Abt Associates Inc., Elizabeth Glaser Pediatric AIDS ...

The link between data and governance are key to making public health supply chains more integrated and responsive in order to get life-saving commodities to those in need. In particular, considering its significant health challenges, poor maternal and child health indicators, and major recent devolution in political authority, Kenya represents a country in need of an innovative revamp of their ...

President's Emergency Plan for AIDS Relief (PEPFAR) and the U.S. Agency for International Development (USAID) under the Cooperative Agreement Strengthening High Impact Interventions for an AIDS-free Generation (AIDSFree), number AID-OAA-A-1400046. AIDSFree is implemented by JSI Research & Training Institute, Inc. with partners Abt Associates Inc., Elizabeth Glaser Pediatric AIDS Foundation, EnC...

President's Emergency Plan for AIDS Relief (PEPFAR) and the U.S. Agency for International Development (USAID) under the Cooperative Agreement Strengthening High Impact Interventions for an AIDS-free Generation (AIDSFree), number AID-OAA-A-1400046. AIDSFree is implemented by JSI Research & Training Institute, Inc. with partners Abt Associates Inc., Elizabeth Glaser Pediatric AIDS Foundation, EnC...

The AIDSFree Prevention Update is made possible by the generous support of the American people with support from the U.S. President's Emergency Plan for AIDS Relief (PEPFAR) and the United States Agency for International Development (USAID) under the Cooperative Agreement Strengthening High Impact Interventions for an AIDS-free Generation (AIDSFree), number AID-OAA-A-14-00046. AIDSFree is imple...

In order to validate the neutron capture cross section in 241Am, comparisons of calculations with activation experiments at TRIGA reactor JSI and pile oscillation measurements MINERVE CEA Cadarache were done. The results suggest that evaluation new test library JEFF-4T1 on average provide an improvement C/E compared existing nuclear data releases. However, due some discrepancies, additional as ...

Sixty R3SiX/solvent (S) and R2HSiX/S systems with R ) methyl, ethyl, butyl and S ) methylene chloride, DMPU, DMSO, sulfolane, HMPA, acetonitrile, pyridine, N-methylimidazole, and triethylamine were investigated with the help of NMR spectroscopy for different concentration ratios of R3SiX/S and R2HSiX/S as well as different temperatures. With the help of measured δ29Si and δ13C chemical shifts a...

BACKGROUND Idiopathic pulmonary fibrosis (IPF) is the most rapidly progressive and fatal fibrotic disorder, with no curative therapies. The signal transducer and activator of transcription 3 (STAT3) protein is activated in lung fibroblasts and alveolar type II cells (ATII), thereby contributing to lung fibrosis in IPF. Although activation of Janus kinase 2 (JAK2) has been implicated in prolifer...