The joint structural importance (JSI) is an important measure of how two components interact in contributing to the system reliability. The value of JSI is positive (negative) if and only if one component becomes more important (less important) when the other works. A consecutive-k-out-of-n system is a linear arrangement of n components such that the system is failed if and only if some consecu...

Abslruct-In a coded frequency-hopped M-ary frequency shift-keying (FHlMFSK) communication system, it is known that if perfect side information about the jamming state is available to the decoder, substantial improvement in performance is possible. However, thermal noise, which is present in practical communication systems, can corrupt the jamming state information (JSI). In this paper, when JSI...

Phosphorylation of STAT3 on serine 727 regulates gene expression and is found to be elevated in many B-leukemia cells including chronic lymphocytic leukemia (CLL). It is, however, unclear whether targeting STAT3 will be an effective antileukemia therapy. In this study, we assessed in vitro antileukemia activity of the STAT3 inhibitor JSI-124 (cucurbitacin I). JSI-124 potently induces apoptosis ...

Glioblastoma multiforme (GBM) is one of the utmost malignant tumors. Excessive angiogenesis and invasiveness are the major reasons for their uncontrolled growth and resistance toward conventional strategies resulting in poor prognosis. In this study, we found that low-dose JSI-124 reduced invasiveness and tumorigenicity of GBM cells. JSI-124 effectively inhibited VEGF expression in GBM cells. I...

A variety of cancers, including malignant gliomas, show aberrant activation of STAT3, which plays a pivotal role in negative regulation of antitumor immunity. We hypothesized that inhibition of STAT3 signals would improve the efficacy of T cell adoptive transfer therapy by reversal of STAT3-induced immunosuppression in a murine GL261 intracranial glioma model. In vitro treatment of GL261 cells ...

A known jamming state information (JSI) scheme for a coded frequency-hopped M-ary frequency-shift-keying (FH/MFSK) system under partial-band noise jamming, plus additive white Gaussian noise, utilizes the maximum a posteriori (MAP) rule based on the total energy received in the M-tone signaling bands. It is assumed that the knowledge of partial-band noise jamming fraction is available to the JS...

It is knownlhat partial-band tone jamming (PBTJ) is generally the worst form of jamming for frequency-hopped M-ary FSK (FH/MFSK) communication systems. Recent studies show that for some coded systems, full-band noise jamming (FBNJ) is more effective than worst-case PBTJ if a receiver is able to utilize jamming state information (JSI) for decoding, when the symbol energy-to-uniform noise jamming...

Constitutively activated, tyrosine-phosphorylated signal transducer and activator of transcription (STAT) 3 plays a pivotal role in human tumor malignancy. To discover disrupters of aberrant STAT3 signaling pathways as novel anticancer drugs, we developed a phosphotyrosine STAT3 cytoblot. Using this high throughput 96-well plate assay, we identified JSI-124 (cucurbitacin I) from the National Ca...

The Journal of Social Intervention: Theory and Practice (JSI) is an open access, double blind peer reviewed academic Journal. JSI aims to promote available research reflections on practice in social intervention Netherlands Flanders international readership academics professionals. subjects featured the reflect a broad range interventions, since concept relevant for different domains.SponsorsJS...

Abnormal dendritic cell differentiation and accumulation of immunosuppressive myeloid cells in cancer is one of the major factors of tumor nonresponsiveness. We have previously shown that hyperactivation of the Janus-activated kinase 2/signal transducers and activators of transcription 3 (JAK2/STAT3) induced by tumor-derived factors (TDF) is responsible for abnormal dendritic cell differentiati...