PURPOSE The purpose of this study was the morphologic and genetic characterization of the novel eye size mutant Aca23 in the mouse. METHODS The eyes of the mutants were characterized in vivo by optical low-coherence interferometry, Scheimpflug imaging, and funduscopy. Visual acuity was examined using a virtual optomotor system. Morphology was studied by histology, in situ hybridization, and i...

A 3-months old infant born to non-consanguineous parents was evaluated for hypotonia and developmental delay. He had a cataract in left eye, congenital glaucoma and megalocornea in right eye with no other dysmorphism. Anterior fontanelle was widely open. He was hypotonic with diminished tendon reflexes. Hypermobility was noted around both elbows and knees. There were unusual multiple skin folds...

A 44-year-old man with anterior megalophthalmos arrived at the clinic presenting a cataract in the right eye. The corneal diameter was 13 mm. Iridodonesis and phacodonesis were evident during slit lamp examination. Anterior chamber depth was 5.89 mm, and the diameter of the capsular bag was approximately 14.45 mm. Due to the large capsular bag, a standard posterior chamber intraocular lens was ...

OBJECTIVE To determine the ophthalmic indications and challenges for pediatric ocular examination under anesthesia (EUA). METHODS The surgical register and patients' records of children who underwent EUA between 1990 and 2007 were examined to document patients' bio data, diagnoses and details of procedures and anesthesia. RESULTS Thirty-nine children underwent EUA during the 18-year period....

The cyanide overload of 40 cassava (gari) processing workers, 25 frequent consumers of cassava foods and 20 cigarette smokers (all Nigerians) were assessed using a new simple kit method for determination of thiocyanate (cyanide metabolite) in urine. The mean thiocyanate measured in the urine of three groups of cassava processing workers were 9.48±2.8, 8.70±2.23, and 7.46±2.57 ppm. The mean thio...

Organ retrieval provides a service to both recipients and donor families. Many patients and their families wish to donate organs at the time of death and eye donation is rarely contraindicated. Corneal transplantation is a commonly performed procedure in Canada and is done either to restore sight or eye integrity. Corneal scarring, degeneration and dystrophy, keratoconus and keratoglobus are co...

Megalocornea in isolation is a rare congenital enlargement of the cornea greater than 13 mm in diameter. Patients with megalocornea are prone to cataract formation, crystalline lens subluxation, zonular deficiencies and dislocation of the posterior chamber intraocular lens (PCIOL) within the capsular bag. A 55-year-old male with megalocornea in isolation developed subluxation of the capsular ba...

Anterior megalophthalmos is characterized by megalocornea associated with a very broad anterior chamber and ciliary ring elongation. It is also called X-linked megalocornea. It is accompanied by early development of cataracts, zonular anomalies, and, rarely, vitreoretinal disorders. Subluxation of a cataract can occur in cataract surgery because of zonular weakness. In addition, in most patient...

Keratoconus is a bilateral noninflammatory corneal ectasia with an incidence of approximately 1 per 2,000 in the general population. It has well-described clinical signs, but early forms of the disease may go undetected unless the anterior corneal topography is studied. Early disease is now best detected with videokeratography. Classic histopathologic features include stromal thinning, iron dep...

Clinical Features (Fig. 1, overleaf) The condition appears to be asymptomatic and presents as a chance clinical finding. The corneal lesions are round, discrete dense opacities 0 5 mm. or less in diameter. They lie at the level of Bowman's membrane and usually extend just into the superficial stroma. The typical lesion has a striking white or creamy, rather porous-looking centre, and this is su...