" Keratoglobus, also known as megalocomea, is usually accompanied by infantile hydrophthalmos or glaucoma" (Bietti, 1925). " There is a form of ectasia of the bulb known as hydrophthalmos, megalophthalmos, or also, because the enlargement of the cornea particularly attracts our attention, as megalocornea or keratoglobus: the affection is congenital or appears shortly after birth without any app...

OBJECTIVE To examine histopathologic and immunohistochemical features of human corneal buttons from patients who developed keratoglobus. METHODS Nine corneal buttons were obtained during penetrating keratoplasty from patients with keratoglobus. Histologic features were examined using hematoxylin-eosin-stained sections. Immunohistochemical staining for alpha1-proteinase inhibitor, Sp1, and mat...

" Keratoglobus, also known as megalocomea, is usually accompanied by infantile hydrophthalmos or glaucoma" (Bietti, 1925). " There is a form of ectasia of the bulb known as hydrophthalmos, megalophthalmos, or also, because the enlargement of the cornea particularly attracts our attention, as megalocornea or keratoglobus: the affection is congenital or appears shortly after birth without any app...

We aimed to describe congenital keratoglobus with blue sclera in two siblings with overlapping Marshall/Stickler phenotype. Two sisters (ages four and six) with bilateral high astigmatism were evaluated by slit-lamp microscopy. Corneal topography and pachymetry maps were also obtained. Slit-lamp examination revealed that both corneas were globular in shape with peripheral corneal thinning. Pach...

Background: Keratoglobus is a rare noninflammatory corneal disorder characterized by diffuse corneal thinning and globular protrusion of the cornea. Surgical management of keratoglobus is challenging and the standard method has not yet been defined. Aim: To present the role of large penetrating keratoplasty (PK) in the management of keratoglobus. Case Presentation: A 29-year-old male patient wi...

An Indian case of Alport's syndrome who had association of keratoglobus and blue sclerae is described.

We were very interested to read of a second mutation in the seed region of miR-184 resulting in EDICT syndrome. We were unsure after reading the paper, however, of how the corneal findings should be classified and of the statement that the family “does not demonstrate a keratoconus phenotype.” Keratoconus, the commonest disorder of corneal thinning and steepening, has been linked with VSX1 and ...

Purpose. To report the use of Descemet stripping endothelial keratoplasty (DSEK) in a patient with keratoglobus and chronic hydrops. Case Report. We describe a case of a 28-year-old man with bilateral keratoglobus and chronic hydrops in the right eye secondary to spontaneous Descemet membrane tear. The patient presented with finger counting (CF) vision, itching, foreign body sensation, and seve...