Background: Soil and plant contamination in copper exposure causes chronic copper poisoning (CCP) in animals following the consumption of plants in these soils. Objectives: The present study was carried out on 10 clinically affected copper poisoned cases (in each season) from autumn 2015 to the end of summer 2016, in four seasons in Kerman province to evaluate the seasonal effects of CCP in she...

Objective(s):This study was planned to appraise the protective effect of Nigella sativa fixed oil (NSO) against subchronic ethanol induced toxicity in rats. Materials and Methods: Studies were carried out on six groups of six animals each, including control (normal saline, gavage), ethanol (3 g/kg/day, gavage), NSO (0.125, 0.25 and 0.5 ml/Kg/day, IP) plus ethanol and NSO (0.5 ml/Kg/day, IP) gro...

The aim of this study was to investigate acute toxicity (96-hr LC50 and lethal concentrations) of waterborne metal mixture (Pb+Mn) for the fish, Catla catla, Labeo rohita, Cirrhina mrigala, Ctenopharyngodon idella and Hypophthalmichthys molitrix. The extent of metals bio- accumulation in fish body organs viz. gills, liver, kidney, fins, bones, muscle and skin at both 96-hr LC50 and lethal conce...

Tenofovir disoproxil fumarate, the prodrug of nucleotide reverse transcriptase inhibitor tenofovir, shows high efficacy and relatively low toxicity in HIV patients. However, long-term kidney toxicity is now acknowledged as a modest but significant risk for tenofovir-containing regimens, and continuous use of tenofovir in HIV therapy is currently under question by practitioners and researchers. ...

Background: The risk of injury to the kidney can be significantly exacerbated by presence tumors and effects related treatments. Kidney associated with cancer is common in multiple myeloma, tumor lysis syndrome, hematopoietic stem cell therapy, chemotherapy. Cancer patients are at increased infection, sepsis, drug-related toxicity, other comorbidities, leading a acute (AKI). This study retrospe...

occupational exposure to toluene is associated with development and progression of renal failure. however, the cellular mechanisms by which these agents cause renal dysfunction and injury remain elusive. the present study investigates the effect of toluene on animal model (rat) kidney to present a broader understanding of the mechanism by which toluene causes renal injury. adult male rats recei...

Kidney toxicity is one of the most frequent adverse events reported during drug development. The lack of accurate predictive cell culture models and the unreliability of animal studies have created a need for better approaches to recapitulate kidney function in vitro. Here, we describe a microfluidic device lined by living human kidney epithelial cells exposed to fluidic flow that mimics key fu...

objective(s):this study was planned to appraise the protective effect of nigella sativa fixed oil (nso) against subchronic ethanol induced toxicity in rats. materials and methods: studies were carried out on six groups of six animals each, including control (normal saline, gavage), ethanol (3 g/kg/day, gavage), nso (0.125, 0.25 and 0.5 ml/kg/day, ip) plus ethanol and nso (0.5 ml/kg/day, ip) gro...

Signs and symptoms of D PH toxicity were seen in an epileptic child who had received DPH and MP concurrently. In the absence of liver and kidney disease and any intercurrent infection, and with the patient's recovery following the withdrawal of DPH, it appears that drug-drug interaction is the most logical explanation for DPH intoxication.