Catechols are substances with a 1,2-dihydroxybenzene group from natural or synthetic origin. The aim of this study was to determine whether catechols (4-methylcatechol, 4-nitrocatechol, 2,3-dihydroxynaphthalene) and the antiparkinsonian drugs, entacapone and tolcapone, at doses 150 to 300 mg/kg/day, for 3 days, are able to enhance their own glucuronidation. The induction potency of catechols on...

20-Hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE) is a principal arachidonic acid (AA) metabolite formed via P450-dependent oxidation in hepatic and renal microsomes. Although 20-HETE plays an important role in the regulation of cell and/or organ physiology, the P450 enzyme(s) catalyzing its formation in humans remain undefined. In this study, we have characterized AA omega-hydroxylation to ...

Graph Rubbling: An Extension of Graph Pebbling Christopher Andrew Belford Place a whole number of pebbles on the vertices of a simple, connected graph G; this is called a pebble distribution. A rubbling move consists of removing a total of two pebbles from some neighbor(s) of a vertex v of G and placing a single pebble on v. A vertex v of G is called reachable from an initial pebble distributio...

Salinized lake basins have distinctive sedimentary response characteristics, similar to marine shallow-water carbonate platforms. High-frequency cycles can also be used reveal more sedimentological information, such as relative lake-level fluctuations, lithofacies sequence combinations, and paleogeographic evolution. In this article, a comprehensive study on the stratigraphic shelf delineation ...

The essential oil yield stability of damask rose (Rosa damascena Mill.) as an important medicinal and aromatic plant in different environments has not been well documented. In order to determine appropriate stability parameters, six statistics were studied for essential oil stability of 35 Rosa damascena landraces in seven locations (Sanandaj, Arak, Kashan, Dezful, Stahban, Ke...

Although non-R&D innovation activities account for a signi…cant portion of innovation e¤orts carried out across very heterogeneous economies in Europe, how to incorporate them in to economic models is not always straightforward. For instance, the traditional macro approach to estimating the determinants of total factor productivity (TFP) does not handle them well. To counter these problems, thi...