Abstract Background: Reduced Nitric oxide (NO) synthesis has been reported in hypothyroidism. NO has many physiological and pathological roles. The purpose of this study was to determine NO metabolites, nitrate and nitrite (NOx), levels in serum and tissues of heart, brain, cerebellum and aorta of rats with fetal hypothyroidism. . Materials and methods: Hypothyroidism was induced in female rats...

Abstract Background: Anxiety is a psychological and physiological state characterized by somatic, emotional, cognitive, and behavioral components. Anxiety is considered to be a normal reaction to stress, however excessive anxiety results in anxiety disorder. In this study, we investigated the possible interaction between nicotine and nitric oxide system of the dorsal hippocampus on anxiety-l...

  Background: Multiple sclerosis (MS ( is one of the chronic autoimmune diseases of the central nervous system with unknown etiology. Nitric oxide (NO) as a free radical has contradictory effect on the central nervous system and on MS disease. Nitric oxide is one of the distractive factors of the immune system and is a factor in the destruction of myelin. On the other hand, there is an interact...

Background: Nitric oxide (NO) is produced in different body organs in mammals and numerous physiological and pathological properties are attributed to this small molecule. The precursor of this substance in the body, L-arginine, is synthesized by the enzyme nitric oxide synthase (NOS), and it is catalyzed, and is inhibited by a substance called L-NG-nitroarginine methyl ester (L-NAME). In this ...

Introduction: Previous studies shows L-arginin (nitric oxide precursor) increases conditioned place preference and drug seeking behaviors whereas LG-nitro-arginine methyl ester) L-NAME( as nitric oxide synthase inhibitor decreases this process. In this project, effects of intra-central amygdale bilateral injection of nitric oxide agents on drug-seeking behaviors including rearing, sniffing and ...