Oral administration of drugs has received significant attention in the last 1, 2 decades, as it is most comfortable and painless route, which leads to high patient compliance. Although oral delivery shows positive effects patients, several hurdles must be overcome such enzymatic degradation, large pH-variations found throughout gastrointestinal (GI) tract, continuous mucus secretion. We have st...

Purpose: To compare solvent evaporation and ultrasonic assisted synthesis in preparation of nimesulide nanosponges using polyvinyl-alcohol Eudragit L100 as a polymer/copolymer dichloromethane cross linker.Methods: Twelve formulations were prepared, six with each method by varying the ratios both polymer co-polymer. The resulting evaluated characterized preformulation studies, production yield (...

BACKGROUND Success of any gene therapy protocol relies mostly on using an efficient carrier to direct nucleic acid to the place of action. The system should also have transfection ability at release site. Different routes are available for delivering genetic materials to the target organs, amongst them; oral delivery is particularly attractive for certain reasons. However, serious obstacles, li...