This chapter discusses the positive effects of IT investment on firm financial performance when a distinct range of characteristics is examined. The relationship between IT investment and firm performance considering the information intensity of the industry is explored using a distributed lag model. Findings indicate both a positive effect and a positive lag effect of IT investment. The effect...

Abstract—In many cases, there are some time lag between the consumption of inputs and the production of outputs. This time lag effect should be considered in evaluating the performance of organizations. Recently, a couple of DEA models were developed for considering time lag effect in efficiency evaluation of research activities. Multi-periods input(MpI) and Multi-periods output(MpO) models are...

This research extends extant literature examining the relationship between IS use and performance. While prior theory has predominantly treated IS use as an antecedent of performance and hypothesized a positive effect of use on performance, this research provides an alternative perspective. Specifically, this paper theorizes that under certain contexts performance can be an antecedent of use an...

BACKGROUND Lag screw cut-out failure following fixation of unstable intertrochanteric fractures in osteoporotic bone remains an unsolved challenge. This study tested if resistance to cut-out failure can be improved by using a dual lag screw implant in place of a single lag screw implant. Migration behavior and cut-out resistance of a single and a dual lag screw implant were comparatively evalua...

Lymphocyte Activation Gene - 3 (LAG-3) is an immune checkpoint molecule that regulates both T-cell activation and homeostasis. However, the molecular mechanisms underlying LAG-3's function are generally unknown. Using a model in which LAG-3 blockade or absence reliably augmented homeostatic proliferation in vivo, we found that IL-2 and STAT5 are critical for LAG-3 function. Similarly, LAG-3 blo...

The distributed lag effect of ambient particulate air pollution that can be attributed to all cause mortality in Kathmandu valley, Nepal is estimated through generalized linear model (GLM) and generalized additive model (GAM) with autoregressive count dependent variable. Models are based upon daily time series data on mortality collected from the leading hospitals and exposure collected from th...