Resumen.—La molécula de hemoglobina juega un papel clave en el transporte de oxígeno. Hemoglobinas con gran afinidad por el oxígeno son adaptativas en ambientes hipóxicos. Para ampliar nuestro conocimiento acerca de la adaptación a la hipoxia de altura, se extrajo ARN de la médula ósea de seis espécimenes de Lophonetta specularioides de los Andes centrales de Perú (4218–4605 m) y se secuenciaro...

Nowadays non-alcoholic fatty liver disease (NAFLD) is becoming the most common chronic liver pathology both in adults and children. NAFLD manifestation ranges from a simple liver steatosis to steatohepatitis (nonalcoholic steatohepatitis - NASH), which may progress to advanced fibrosis, cirrhosis and end-stage liver disease. Due to the coexistence of visceral obesity, insulin resistance and dys...

The importance of dietary omega-6 to omega-3 (ω6:ω3) fatty acid (FA) ratios for human health has been extensively examined. However, its impact on fish physiology, and the underlying molecular mechanisms, are less well understood. This study investigated influence plant-based diets (12-week exposure) with varying ω6:ω3 (0.4–2.7) hepatic transcriptome Atlantic salmon. Using 44 K microarray analy...

AIM β-catenin signaling is a major oncogenic pathway in hepatocellular carcinoma (HCC). Since β-catenin phosphorylation by glycogen synthase kinase 3β (GSK3β) and casein kinase 1ε (CK1ε) results in its degradation, mutations affecting these phosphorylation sites cause β-catenin stabilization. However, the relevance of missense mutations in non-phosphorylation sites in exon 3 remains unclear. Th...