Permanent hypothyroidism following surgical resection in a patient with Graves' disease requires levo-thyroxine replacement therapy for the rest of the patient's life . We mentioned' one therapeutic regimen for this patient in our first report on the autotransplantation of cryopreserved thyroid tissue in a patient with irreversible hypothyroidism. In this second report, we present the findings ...

Bacterial biofilms can initiate chronic infections that become difficult to eradicate. There is an unmet need for effective therapeutic strategies control and inhibit the growth of these biofilms. Herein, light sensitive mesoporous silica nanoparticles (MSNs) with photothermal (PTT) antimicrobial combined capabilities have been developed. These nanosystems high potential affect bacterial biofil...

Timolol maleate is a non-selective beta-adrenergic receptor blocking agent. Its chemical name is (-)-1-(tert-butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanol maleate (1:1) (salt). Timolol maleate possesses an asymmetric carbon atom in its structure and is provided as the levo-isomer. The optical rotation of timolol maleate is: 25° [α] in 1.0N HCl (C = 5%) = -12.2° (-11.7° to -...

HPLC method was developed for the analysis of Levo Dopa in formulations. In this method we focused on easy and more accuracy. A mixture of Acetonitrile: Methanol: orthophosphoric acid in the ratio of 30:50:20, v/v/v was prepared and used as mobile phase. The mobile phase is 6.8. The wave length of U.V detector 280 nm. We obtained a good resolution peak 2.4 min. The linearity of method is 10-25 ...

Levamisole, the levo-isomer of tetramisole, is readily soluble in water and is rapidly absorbed from the gastro intestinal tract; peak blood levels are achieved after 1.5–4 h. Its plasma half-life is 16 h and it is metabolized mainly in the liver.[1,3] Usually, it is administered at a dose of 150 mg/day for 2–4 days each week but for the management of malignancies or immunodeficiencies a higher...

In this work, racemic hybrid polypeptides poly(ethylene glycol) (PEG)-b-poly(racemic-leucine) (PRL) copolymers with different leucine residues have been synthesized and characterized. Using docetaxel as a model molecule, the high drug-loaded spherical micelles based on PEG-PRL were prepared successfully using dialysis, with a tunable particle size from 170 nm to 250 nm obtained by changing the ...

A 39-year-old man was referred for echocardiography because of dyspnoea, chest pain and murmur. Main finding was a globular morphology of left ventricle with apical hypertrophy and a seemingly cleft mitral valve with mild mitral regurgitation. Trans-oesophageal echocardiography confirmed the ventricular hypertrophy and regurgitation but showed the aortic valve to lie anteriorly and to the left ...