introduction cutaneous mucormycosis is a rare opportunistic infection caused by zygomycetes class of fungi that is often fatal, requiring aggressive local control as well as systemic therapy. few cases of mucormycosis were described in patients with liver cirrhosis, mostly rhino-orbital. to our knowledge, only two cases of upper extremity involvement was reported in cirrhosis while a few cases ...

Background. Postoperative failure is a major cause of adverse outcomes in extensive liver resection. Post-resection requires intensive, including extracorporeal, care. Issues correcting warrant novel approaches to prevent severe cases. Materials and methods. A retrospective analysis 228 various-extent resections included minor (55.7 %), (26.8 %) extended (17.5 operations for malignant, benign p...

Introduction Acute liver failure is a fatal syndrome attributed to massive hepatocyte apoptosis that is resistant to conventional medical therapies. Consequently, liver transplantation is required in many cases. An experimental liver failure model induced by galactosamine (Gal) and lipopolysaccharide (LPS) mimics clinical acute liver failure. In this model, LPS stimulates macrophages to release...

Liver failure in neonates is a rare but often fatal disease. Trisomy 21 is not usually associated with significant infantile liver disease. If present, hepatic dysfunction in an infant with Trisomy 21 is likely to be attributed to transient myeloproliferative disorder with hepatic infiltration by hematopoietic elements and may be associated with secondary hemosiderosis. A less commonly recogniz...

Hepatectomies are among some of the most complex operative interventions performed. Mortality rates after major hepatectomy are as high as 30%, with post-hepatic liver failure (PHLF) representing the major source of morbidity and mortality. We present a review of PHLF, including the current definition, predictive factors, pre-operative risk assessment, techniques to prevent PHLF, identification...

The thienopyridine derivative clopidogrel (CPG) inhibits ADP-induced platelet activation. It is rapidly hydrolysed in the liver via cytochrome P450 enzymes, by an irreversible and NADPHdependent mechanism. Clopidogrel therapy is indicated in the prevention of thrombotic events in patients with acute coronary syndromes, ischemic stroke and peripheral arterial disease or after percutaneous stent ...

Acute liver failure in children is associated with a high mortality. Most cases in our setup are due to water borne hepatotropic viruses HAV and HEV. The clinician must be aware of the earliest and the subtle signs of acute liver failure to identify cases early enough and institute supportive therapy. Focus of therapy has to be on prevention, early recognition and appropriate management of comp...

To cite: Cheung VTF, Singanayagam J, Molyneux A, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2015212522 DESCRIPTION A 54-year-old man presenting with dysphagia, weight loss, epigastric pain and cervical lymphadenopathy was referred directly to endoscopy. The medical history included hypertension and hypercholesterolaemia. Blood tests showed normal bilir...

In considering a patient in liver failure it is important to distinguish between fulminant hepatic failure (FHF) and episodes of acute hepatic decompensation in patients suffering from chronic liver disease (CLD), as the basis for treatment differs. Fulminant hepatic failure has been defined by Trey and Davidson (1970) as encephalopathy developing within 8 weeks of the onset of symptoms in a pa...