Histone deacetylase inhibitors have gained a great deal of attention recently for the treatment of cancers and inflammatory diseases. So design of new inhibitors is of great importance in pharmaceutical industries and labs. Creating pharmacophor models in order to design new molecules or search a library for finding lead compounds is of great interest. This approach reduces the overall cost ass...

Molecular docking is an efficient method to predict the conformations adopted by the ligand within the target binding site. Usually, standard docking protocol involves only one structure to represent the receptor, overlooking the changes in the binding pocket geometry induced by ligand binding. In our previous work, we observed that different conformations of the same target show different volu...

Location decision in distribution Centers is often one of the most critical fundamentals in an organization’s success. This paper gathers some recent applications related to DC location decision for general approaches in logistic environment and in supply chain environment. The sight in location variables and methodology also illustrates and guides to future prospects.

the world health organization (who) has supported and recommended study and research on the various aspects of leishmaniasis which is one of the six major tropical region diseases. cutaneous leishmaniasis is considered as a common parasitic disease in iran. considering the fact that few studies have been conducted about some centers of disease such as khorram-shahr and the information about the...

extended abstract 1. introduction one of the important issues in crisis management is providing settlement and help to the injured. in fact, the location of rescue and help centers should be designed in such a way that after the incident, there is the best chance ofgiving response to victims. in this regard, one of the important tasks of urban planners is to identify suitable locations for evac...

To improve efficiency and sustainability in synchromodal logistics, it becomes crucial to mitigate the disruptive effects caused by non-synchronized operations. In this work, we study Synchronized Location-Transshipment Problem which decisions on facilities select are fundamental ensure synchronization of flows correct exploiting just-in-time logistics cross-docking We propose a Mixed-Integer L...

We study the quality ranking of different information structures. In a unified setting, we present eight representations of essentially the same notion that may arise in distinct literatures, and also establish the intricate relationships among them. The forms that are less familiar to researchers turn out to be more relevant to the operations management context. We also relate the information ...