Background: Lead neurotoxicity is a major health problem known as a risk factor for neurodegenerative diseases, including the manifestation of parkinsonism-like disorder. While lead is known to preferentially accumulate in basal ganglia, the mechanisms underlying behavioral disorders remain unknown. Here, we investigated the neurophysiological and biochemical correlates of motor deficits induce...

Although alcoholism is a worldwide problem resulting in millions of deaths, only a small percentage of alcohol users become addicted. The specific neural substrates responsible for individual differences in vulnerability to alcohol addiction are not known. In this study, we used rodent models to study behavioral and synaptic correlates related to individual differences in the development of eth...

objective: the cerebellum is a key structure involved in coordinated motor planning, cognition, learning and memory functions. this study presents a permanent model of a toxin produced cerebellar lesion characterized according to contemporary motor and cognitive abnormalities. materials and methods: in this experimental study, slow administration of quinolinic acid (qa, 5 μl of 200 μmol, 1 μl/m...

Circadian clocks control many self-sustained rhythms in physiology and behavior with approximately 24-hour periodicity. In many organisms, oxidative stress and aging negatively impact the circadian system and sleep. Conversely, loss of the clock decreases resistance to oxidative stress, and may reduce lifespan and speed up brain aging and neurodegeneration. Here we examined the effects of clock...

Rett syndrome (RTT), a neurodevelopmental disorder primarily affecting females, is accompanied by behavioral and neuropathological abnormalities and decreases in brain cholinergic markers. Because the cholinergic system is associated with cognitive and motor functions, cholinergic deficits in RTT may underlie some of the behavioral abnormalities. In rodents, increased choline availability durin...

Summary Brain neurons play a central role in organismal aging, but there is conflicting evidence about the of neuronal glucose availability because uptake and metabolism are associated with both aging extended life span. Here, we analyzed metabolic changes brain Drosophila during aging. Using genetically encoded fluorescent adenosine triphosphate (ATP) biosensor, found decreased...

Abstract Gene mutations causing cytoplasmic mislocalization of the RNA-binding protein FUS lead to severe forms amyotrophic lateral sclerosis (ALS). Cytoplasmic accumulation is also observed in other diseases, with unknown consequences. Here, we show that drives behavioral abnormalities knock-in mice, including locomotor hyperactivity and alterations social interactions, absence widespread neur...

Over 38 million people worldwide are living with HIV/AIDS, and more than half of them affected by HIV-associated neurocognitive disorders (HAND). Such characterized chronic neuroinflammation, neurotoxicity, central nervous system deterioration, which lead to short- or long-term memory loss, cognitive impairment, motor skill deficits that may show gender disparities. However, the underlying mech...