activated macrophages have been classified into classical (m1) and alternative (m2) macrophages. we aimed to establish a method to yield enough number of macrophages to analyze their molecular, biological and immunological functions. we used drugs; adjuvant albumin from chicken egg whites—imject alum (ova- alum) and ova complete freund adjuvant (ova-cfa), to induce macrophages to m2 and m1 resp...

In this study, we fabricated PCL-nanoparticles by encapsulating dual drugs as amphotericin B and doxorubicin via double-emulsion solvent evaporation method also incorporated with ligand-lectin for targeting the infested macrophage cells and prove importance against VL. Different independent processing parameters were assessed systematically to enhance the incorporation of the dual agents with d...

introduction genetic background has known to be associated with the outcome of human t cell lymphotropic virus (htlv) type i infection. in the present study we investigate the association between gm-csf gene polymorphisms with the outcome of htlv-i infection. materials and methods we analyzed 3 single-nucleotide polymorphisms in the promter region of granulocyte macrophage colony stimulating fa...

Oja depth (Oja 1983) is a generalization of the median to multivariate data that measures the centrality of a point x with respect to a set S of points in such a way that points with smaller Oja depth are more central with respect to S. Two relationships involving Oja depth and centers of mass are presented. The first is a form of Centerpoint Theorem which shows that the center of mass of the c...

IMMUNOLOGICAL EFFECTS OF FLGE2 RECOMBINANT PROTEIN IN HELICOBACTER PYLORI ON TNF-A CYTOKINE PRODUCTION MACROPHAGE CELLS VITRO

the macrophages role within the tumor microenvironment has amended by a variety of factors, thus serves a vital role in tissue morphogenesis. the role of macrophages in health and disease differs enormously as the macrophage has shown dual functions. macrophage has a basic role in antigen presentation serving as the first line of defense in diseases. however the presence of cytokines and growth...

balb/c mice are highly susceptible to infection with the protozoan parasite leishmania major. this susceptibility has been attributed in part to the expansion of th2 cells and production of their cytokines, il-4 and il-10 and down-regulation of th1 cytokine, inf-γ. the inability of susceptible hosts to mount the immune response necessary to activate macrophage and destroy the parasites can be d...

background: the aim of this study was to characterize the leishmania parasites isolated from cuta­neous leishmaniasis (cl) patients in fars province in iran and to compare the potential infectivity of the isolates in macrophage cell line. moreover, attempt was made to find out the association between parasite infectivity and their zymodems. methods: twenty samples were taken from the skin lesio...