in this work we synthesized nano hydroxyapatite (hap)  by sol-gel method, then we functionalized hydroxyapatite nanoparticle by use of  3-aminopropyl trimethoxysilane (aptms) , to improve the loading and control release of sulfasalazine drug bonded to aptms. the drug release patterns from sulfasalazine loaded hap nanoparticles at ph value 8 for 6h, sulfasalazine loaded functionalized hap nanopa...

insulin-loaded biodegradable chitosan nanoparticle was prepared by the polyelec-trolyte complex formation method. the prepared nanoparticles were in the size of 110 nm and had high entrapment (91.0%) capacity. the transdermal nanoinsulin was characterized by in vivo hypoglycemic effects. plasma glucose was decreased to the range of 80.34 to 96.74 mg/dl, and insulin levels were increased to the ...

In this study, the preparation and in vitro characterisation of metformin HCl-loaded CS-PLGA nanoparticles (NPs) were aimed. The prepared nanoparticles (blank nanoparticles (C-1), 50 mg of metformin HCl loaded nanoparticles (C-2) and 75 mg of metformin HCl loaded nanoparticles (C-3) ranged in size from 506.67±13.61 to 516.33±16.85 nm and had surface charges of 22.57±1.21 to 32.37±0.57 mV. Low e...

The kinetics and intricate interactions governing the growth of 3D single nanoparticle (NP) superlattices (SLs, SNSLs) and binary NP SLs (BNSLs) in solution are understood by combining controlled solvent evaporation and in situ, real-time small-angle X-ray scattering (SAXS). For the iron oxide (magnetite) NP SLs studied here, the larger the NP, the farther apart are the NPs when the SNSLs begin...

In this paper the results concerning the synthesis of magnetite (Fe₃O₄) nanoparticles (NPs), their functionalization using silane derivatives, such as (3-Aminopropyl)triethoxysilane (APTES) and (3-mercaptopropyl)trimethoxysilane (MPTMS), and their exhaustive morphological and physical characterization by field emission scanning electron microscopy (FE-SEM) with energy dispersion X-ray spectrome...

Article history: Received on: 30/08/2013 Revised on: 03/10/2013 Accepted on: 15/10/2013 Available online: 31/10/2013 Azathioprine loaded gelatin microspheres were formulated to control/target drug release in an arthritic joint by magnetic force or intra-articular injection. Glutaraldehyde cross linked microspheres were characterized for drug loading, entrapment efficiency, gas chromatography, m...

Abstract Background Iron oxide nanoparticles, especially nano-magnetite, are promising candidates for use in a variety of applications. The present study aimed to investigate the effect nano-magnetite on reproductive health female Wistar rats. Twenty-one adult rats were divided into three groups: Group 1 served as control group, 2 received low dose 5 mg/kg and 3 high 10 nano-magnetite. For 30 d...

this paper provides an overview of how the surface properties of ferromagnetic nanoparticles dispersed in fluids is modified by natural and biocompatible polymers. among common magnetic nanoparticles, magnetite (fe3o4) and maghemite (g-fe203) are popular candidates because of their biocompatibility. natural polymeric coating materials are the most commonly used biocompatible magnetic nanopartic...

Objective(s): Nanoparticles offer an attractive platform for drug delivery through a wide variety of the body's physiological barriers. Furthermore, modification of nanoparticle surface with moeites such as Poloxamer188 can enhance their accumulation and localization at disease site. In this work, we investigated the physiochemical effect of a scavenger receptor (SR-BI) interac...

Understanding the interactions between natural organic matter (NOM) and zero-valent iron nanoparticles (nano-Fe0) and magnetite nanoparticles (nano-Fe3O4) is essential for evaluating their performance in pollutant remediation, as well as determining their fate and transport in the environment. Batch experiments were performed to investigate the sorption/desorption behaviors of humic acid (HA) o...