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Prior reports have described the mechanism initially responsible for transitional tumor cell adherence and implantation on injured urothelial surfaces. This study further quantifies variables that influence the size of tumor inoculum at the injury site and thereby affect bladder tumor recurrence risk. The surface area of urothelial injury, the concentration of tumor cells in the intravesical ba...
Data defining the isolated effect of insulin on whole body protein and glucose metabolism in cancer patients are limited. Ten normal volun teers (controls), age 55 ±3 years (mean ±SEM); 8 cancer patients, age 61 ±3years, weight loss 2 ±1% (CANWL); and 8 cancer patients, age 55 ±2 years, weight loss 18 ±2% (CAWL), were studied in the postabsorptive state. Whole body leucine kinetics were d...
Major intraabdominal operations result in immunodepression.In ad dition, manipulation of malignant tumors may release tumor cells into the systemicandportal circulation. The additiveeffectsof immunodepres sion and tumor cell releaseduring surgical treatment for gastrointestinal cancer may increase the metastases of tumor to the liver. We, therefore, studied the inhibitory effect of immuiloactiv...
â Novel method creates cases independent of the knowledge acquisition process â Such a creative approach is not doomed to reimplement incorrect knowledge possibly contained in the knowledge base, but may detect it â The morphing method is not performed as a single run but is an iterative process in order to achieve a sufficient test case coverage â Evaluation with medical consultation system: s...
Selective placement of an aliphatic â-alanine (â) residue paired side-by-side with either a pyrrole (Py) or imidazole (Im) aromatic amino acid is found to compensate for sequence composition effects for recognition of the minor groove of DNA by hairpin pyrrole-imidazole polyamides. A series of polyamides were prepared which contain pyrrole and imidazole aromatic amino acids, as well as γ-aminob...
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Background and purpose : Hepatitis  virus (HÂV) vaccination has been advised for patients with chronic liver diseases as HÂV super infection in these patients can result in severe or even fatal disease . Ïn Ïran the indication for HÂV vaccination are not clear due to lack of data on HÂV seroprevalence in patients with chronic liver diseases. The aim of this study was to determine the pre...
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